PCNA antibody (Proliferating Cell Nuclear Antigen)

Details for Product anti-PCNA Antibody No. ABIN6298083
Antigen
  • PCNAR
  • Pcna/cyclin
  • pcna
  • AO090003000846
  • 53/13
  • CG9193
  • DmPCNA
  • Dmel\\CG9193
  • MUS209
  • Mus209
  • PCNA
  • PCNA/mus209
  • Pcna
  • dPCNA
  • l(2)02448
  • l(2)56F
  • l(2)56Fa
  • l(2)s1534
  • cb16
  • fb36g03
  • wu:fa28e03
  • wu:fb36g03
  • pcna-A
  • proliferating cell nuclear antigen
  • DNA polymerase III sliding clamp
  • Proliferating cell nuclear antigen
  • Proliferating cell nuclear antigen-like
  • proliferating cell nuclear antigen L homeolog
  • proliferating cell nuclear antigen 1
  • PCNA
  • Pcna
  • pcna
  • MMP_RS08810
  • ANI_1_512014
  • AOR_1_1500154
  • MGC53867
  • pcna.L
  • pcna1
  • LOC106420145
  • pcn1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
508
272
256
63
51
45
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37
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8
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2
1
1
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1
Host
Rabbit
302
236
4
2
Clonality
Polyclonal
Conjugate
This PCNA antibody is un-conjugated
24
19
11
8
8
8
8
8
8
6
4
4
4
4
4
4
4
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2
2
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2
1
1
1
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1
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1
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Application
411
192
122
121
118
108
77
53
44
34
21
11
10
7
7
4
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3
1
1
1
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Options
Purpose Rabbit Anti-PCNA Antibody,
Plasmids, Primers & others Plasmids, Primers & others PCNA products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name PCNA (PCNA Antibody Abstract)
Background

Target Description: Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'- 5' exonuclease and 3'-phosphodiesterase, but not apurinic- apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.

Gene Symbol: PCNA

Gene ID 5111
UniProt P12004
Pathways Telomere Maintenance, DNA Damage Repair, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Autophagy
Restrictions For Research Use only
Storage 4 °C,-20 °C
Storage Comment 2-8°C (short-term), -20°C (long-term)
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