COL25A1 antibody (AA 155-169)

Catalog No. ABIN636294

Product Details anti-COL25A1 Antibody

Target: COL25A1 (Collagen, Type XXV, alpha 1 (COL25A1))

Binding Specificity: AA 155-169

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COL25A1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity chromatography purified

Immunogen: CLACP antibody was raised in rabbit using AA 155-169 [KGEQGDQGPRMVFPK] of the NC2-2 region of human and mouse CLAC-P as the immunogen.

Isotype: IgG

Application Details

Application Notes: WB: 1:500
Optimal conditions should be determined by the investigator.

Comment:

This antibody producess bands of 50, 70 and 100 kDa in SPs of AD brain, but not in diffuse plaques of non-demented aged individuals, diffuse deposits in sub-cortical structures and cerebellum in AD nor in cerebral amyloid angiopathy.

Restrictions: For Research Use only

Handling

Concentration: Lot specific

Buffer: Affinity purified IgG supplied in PBS with 0.02 % NaN3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term storage. Aliquot and store at -20 °C for long term storage.

Target Details for COL25A1

Target: COL25A1 (Collagen, Type XXV, alpha 1 (COL25A1))

Alternative Name: CLACP (COL25A1 Products)

Synonyms: COL25A1 antibody, AMY antibody, CLAC antibody, CLAC-P antibody, CLACP antibody, 2700062B08Rik antibody, collagen type XXV alpha 1 chain antibody, collagen, type XXV, alpha 1 antibody, COL25A1 antibody, col25a1 antibody, Col25a1 antibody

Background: The 9D2 antigen isolated from senile plaque amyloid was identified as collagen-like Alzheimer amyloid plaque component (CLAC), and its precursor as CLAC-P/collagen type XXV. Both secreted and membrane-tethered forms of CLAC-P/collagen type XXV specifically bind to fibrillized Abeta, implicating these proteins in beta-amyloidogenesis and neuronal degeneration in AD.