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MECP2 antibody (pSer423)

MECP2 Reactivity: Human, Rat WB, IHC (p) Host: Rabbit Polyclonal RB29261 unconjugated
Catalog No. ABIN650833
  • Target See all MECP2 Antibodies
    MECP2 (Methyl CpG Binding Protein 2 (MECP2))
    Binding Specificity
    • 19
    • 11
    • 10
    • 8
    • 7
    • 7
    • 6
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer423
    Reactivity
    • 104
    • 41
    • 30
    • 6
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    Human, Rat
    Host
    • 103
    • 8
    • 1
    Rabbit
    Clonality
    • 104
    • 8
    Polyclonal
    Conjugate
    • 66
    • 10
    • 8
    • 8
    • 7
    • 7
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MECP2 antibody is un-conjugated
    Application
    • 82
    • 66
    • 36
    • 31
    • 12
    • 10
    • 8
    • 7
    • 5
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Predicted Reactivity
    Pr, M
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This MeCP2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S423 of human MeCP2.
    Clone
    RB29261
    Isotype
    IgG
    Top Product
    Discover our top product MECP2 Primary Antibody
  • Application Notes
    WB: 1:500. WB: 1:500. WB: 1:500. IHC-P-Leica: 1:500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid freeze-thaw cycles.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.
    Expiry Date
    6 months
  • Qiu, Sylwestrak, Lieberman, Zhang, Liu, Ghosh: "The Rett syndrome protein MeCP2 regulates synaptic scaling." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 32, Issue 3, pp. 989-94, (2012) (PubMed).

    Stansfield, Pilsner, Lu, Wright, Guilarte: "Dysregulation of BDNF-TrkB signaling in developing hippocampal neurons by Pb(2+): implications for an environmental basis of neurodevelopmental disorders." in: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 127, Issue 1, pp. 277-95, (2012) (PubMed).

  • Target
    MECP2 (Methyl CpG Binding Protein 2 (MECP2))
    Alternative Name
    MeCP2 (MECP2 Products)
    Synonyms
    AUTSX3 antibody, MRX16 antibody, MRX79 antibody, MRXS13 antibody, MRXSL antibody, PPMX antibody, RS antibody, RTS antibody, RTT antibody, 1500041B07Rik antibody, BB130002 antibody, D630021H01Rik antibody, Mbd5 antibody, WBP10 antibody, wu:fk96a04 antibody, zgc:111857 antibody, methyl-CpG binding protein 2 antibody, methyl CpG binding protein 2 antibody, methyl-CpG binding protein 2 S homeolog antibody, MECP2 antibody, Mecp2 antibody, mecp2 antibody, mecp2.S antibody
    Background
    DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of some cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.
    Molecular Weight
    52441
    Gene ID
    4204
    NCBI Accession
    NP_001104262, NP_004983
    UniProt
    P51608
    Pathways
    Inositol Metabolic Process, Chromatin Binding, Synaptic Membrane
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