Gasdermin B antibody (AA 208-237)

Catalog No. ABIN652499

Product Details anti-Gasdermin B Antibody

Target: Gasdermin B (GSDMB)

Binding Specificity: AA 208-237

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Gasdermin B antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This GSDMB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 208-237 amino acids from the Central region of human GSDMB.

Clone: RB22342

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-Gasdermin B antibody (ABIN652499)

Das, Miller, Beppu, Mueller, McGeough, Vuong, Karta, Rosenthal, Chouiali, Doherty, Kurten, Hamid, Hoffman, Broide: "GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, Issue 46, pp. 13132-13137, (2018) (PubMed).

Target Details for Gasdermin B

Target: Gasdermin B (GSDMB)

Alternative Name: GSDMB (GSDMB Products)

Synonyms: GSDML antibody, PRO2521 antibody, gasdermin B antibody, GSDMB antibody

Background: GSDMB is a protein with 3' exonuclease activity. Enzymes with this activity are involved in DNA replication, repair, and recombination. Similarity to an E. coli protein suggests that this enzyme may be a subunit of DNA polymerase III, which does not have intrinsic exonuclease activity.

Molecular Weight: 46786

Gene ID: 55876

NCBI Accession: NP_001035936, NP_001159430, NP_001159431, NP_061000

UniProt: Q8TAX9