PDE6C antibody (AA 271-300)

Catalog No. ABIN653683

Product Details anti-PDE6C Antibody

Target: PDE6C (phosphodiesterase 6C, CGMP-Specific, Cone, alpha Prime (PDE6C))

Binding Specificity: AA 271-300

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE6C antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PDE6C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 271-300 amino acids from the Central region of human PDE6C.

Clone: RB24356

Isotype: Ig Fraction

Application Details

Application Notes: IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-PDE6C antibody (ABIN653683)

Xu, Morris, Thapa, Ma, Michalakis, Biel, Baehr, Peshenko, Dizhoor, Ding: "cGMP accumulation causes photoreceptor degeneration in CNG channel deficiency: evidence of cGMP cytotoxicity independently of enhanced CNG channel function." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 33, Issue 37, pp. 14939-48, (2013) (PubMed).

Target Details for PDE6C

Target: PDE6C (phosphodiesterase 6C, CGMP-Specific, Cone, alpha Prime (PDE6C))

Alternative Name: PDE6C (PDE6C Products)

Synonyms: PDE6C antibody, cpfl1 antibody, ACHM5 antibody, COD4 antibody, PDEA2 antibody, phosphodiesterase 6C antibody, phosphodiesterase 6C, cGMP specific, cone, alpha prime antibody, PDE6C antibody, Pde6c antibody

Background: PDE6C is the alpha-prime subunit of cone phosphodiesterase, which is composed of a homodimer of two alpha-prime subunits and 3 smaller proteins of 11, 13, and 15 kDa.

Molecular Weight: 99147

Gene ID: 5146

NCBI Accession: NP_006195

UniProt: P51160