ATP6V1B1 antibody (AA 284-310)

Catalog No. ABIN655485

Product Details anti-ATP6V1B1 Antibody

Target: ATP6V1B1 (ATPase, H+ Transporting, Lysosomal 56/58kDa, V1 Subunit B1 (ATP6V1B1))

Binding Specificity: AA 284-310

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATP6V1B1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Predicted Reactivity: B, M, Rat, E, C, D

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ATP6V1B1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 284-310 amino acids from the Central region of human ATP6V1B1.

Clone: RB24864

Isotype: IgG

Application Details

Application Notes: IF: 1:10~50. WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for ATP6V1B1

Target: ATP6V1B1 (ATPase, H+ Transporting, Lysosomal 56/58kDa, V1 Subunit B1 (ATP6V1B1))

Alternative Name: ATP6V1B1 (ATP6V1B1 Products)

Synonyms: ATP6B1 antibody, RTA1B antibody, VATB antibody, VMA2 antibody, VPP3 antibody, AW208839 antibody, Atp6b1 antibody, D630003L15 antibody, D630030L16Rik antibody, D630039P21Rik antibody, Vpp-3 antibody, Vpp3 antibody, ATPase H+ transporting V1 subunit B1 antibody, ATPase, H+ transporting, lysosomal V1 subunit B1 antibody, ATP6V1B1 antibody, Atp6v1b1 antibody

Background: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain B subunit isoforms and is found in the kidney. Mutations in this gene cause distal renal tubular acidosis associated with sensorineural deafness. [provided by RefSeq].

Molecular Weight: 56833

Gene ID: 525

NCBI Accession: NP_001683

UniProt: P15313

Pathways: Sensory Perception of Sound, Transition Metal Ion Homeostasis, Proton Transport