GSAP antibody (C-Term)
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- Target See all GSAP (PION) Antibodies
- GSAP (PION) (Pigeon Homolog (PION))
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Binding Specificity
- AA 537-565, C-Term
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This GSAP antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Purification
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- Immunogen
- This PION antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 537-565 amino acids from the C-terminal region of human PION.
- Clone
- RB27384
- Isotype
- IgG
- Top Product
- Discover our top product PION Primary Antibody
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anti-Pigeon Homolog (PION) (AA 616-854) antibody
PION Reactivity: Human WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-Pigeon Homolog (PION) (AA 536-565), (C-Term) antibodyPION Reactivity: Human WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
anti-Pigeon Homolog (PION) (N-Term) antibodyPION Reactivity: Human, Rat, Cow, Dog, Horse, Rabbit WB Host: Rabbit Polyclonal unconjugated
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- Application Notes
- WB: 1:1000. IHC-P: 1:10~50
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- PION Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
- Expiry Date
- 6 months
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- Target
- GSAP (PION) (Pigeon Homolog (PION))
- Alternative Name
- PION (PION Products)
- Synonyms
- PION antibody, A530088I07Rik antibody, Pion antibody, gamma-secretase activating protein antibody, GSAP antibody, Gsap antibody
- Background
- Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer disease (AD, MIM 104300). Formation of amyloid-beta is catalyzed by gamma-secretase (see PSEN1, MIM 104311), a protease with numerous substrates. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and its substrate, the amyloid-beta precursor protein (APP, MIM 104760) C-terminal fragment (APP-CTF) (He et al., 2010 [PubMed 20811458]).
- Molecular Weight
- 97802
- Gene ID
- 54103
- NCBI Accession
- NP_059135
- UniProt
- A4D1B5
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