Caspase 9 antibody (Caspase 9, Apoptosis-Related Cysteine Peptidase)

Details for Product anti-CASP9 Antibody No. ABIN6566464
Antigen
Reactivity
Human, Mouse (Murine)
450
162
125
20
14
6
4
3
2
2
1
1
Host
Rabbit
445
37
1
Clonality
Polyclonal
Conjugate
This Caspase 9 antibody is un-conjugated
16
10
10
10
10
10
10
9
6
4
3
3
3
3
3
3
3
Application
Western Blotting (WB)
402
167
158
79
79
51
42
32
24
16
13
10
9
2
2
1
1
Options
Immunogen Recombinant protein of human CASP9
Isotype IgG
Purification Affinity purification
Antigen
Alternative Name CASP9 (CASP9 Antibody Abstract)
Background

Synonyms: APAF-3,APAF3,Apoptosis related cysteine peptidase,Apoptotic protease Mch-6,Apoptotic protease-activating factor 3,CASP-9,CASP9,CASP9,Caspase 9 apoptosis related cysteine peptidase,Caspase 9 Dominant Negative,Caspase 9c,Caspase-9,Caspase-9 subunit p10,ICE LAP6,ICE like apoptotic protease 6,ICE-LAP6,ICE-like apoptotic protease 6,MCH6,PPP1R56,protein phosphatase 1,regulatory subunit 56,RNCASP9

Background: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1, this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants.

Molecular Weight

Observed_MW: 37kDa, 47kDa

Calculated_MW: 17kDa/30kDa/36kDa/46kDa

Gene ID 842
UniProt P55211
Pathways MAPK Signaling, RTK Signaling, Apoptosis, Caspase Cascade in Apoptosis, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Endopeptidase Activity
Application Notes WB 1:500 - 1:2000
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze / thaw cycles.
Supplier Images
Image no. 1 for anti-Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9) antibody (ABIN6566464) Western blot analysis of extracts of various cell lines, using CASP9 antibody.