BCL2L1 antibody (BCL2-Like 1)

Details for Product anti-BCL2L1 Antibody No. ABIN6566501
Antigen
Reactivity
Human, Mouse (Murine), Rat (Rattus)
437
301
283
102
25
18
12
11
11
9
9
6
3
2
1
Host
Rabbit
295
173
3
1
Clonality
Polyclonal
Conjugate
This BCL2L1 antibody is un-conjugated
29
13
8
8
8
8
8
8
7
4
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
1
1
1
1
1
1
Application
Western Blotting (WB)
337
173
140
123
114
79
49
48
27
21
12
9
7
7
6
4
3
2
1
1
Options
Immunogen Recombinant protein of human BCL2L1
Isotype IgG
Purification Affinity purification
Antigen
Alternative Name BCL-x (BCL2L1 Antibody Abstract)
Background

Synonyms: Apoptosis regulator Bcl X,Apoptosis regulator Bcl-X,Apoptosis regulator BclX,B cell lymphoma 2 like,B2CL1,Bcl 2 like 1 protein,Bcl X,Bcl xL,BCL XL/S,Bcl xS,Bcl-2-like protein 1,Bcl2 Like 1,Bcl2 related gene,Bcl2-L-1,BCL2L,Bcl2l1,BCLX,BclXL,BclXs,DKFZp781P2092,PPP1R52,Protein phosphatase 1 regulatory subunit 52

Background: The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator.

Molecular Weight

Observed_MW: 30kDa

Calculated_MW: 18kDa/25-26kDa

Gene ID 598
UniProt Q07817
Pathways Apoptosis, Negative Regulation of intrinsic apoptotic Signaling
Application Notes WB 1:500 - 1:2000
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze / thaw cycles.
Supplier Images
Image no. 1 for anti-BCL2-Like 1 (BCL2L1) antibody (ABIN6566501) Western blot analysis of extracts of various cell lines, using BCL2L1 antibody.