Insulin Receptor Substrate 1 (IRS1) antibody

Details for Product No. ABIN6566530
Antigen
Reactivity
Human, Mouse (Murine)
621
457
431
32
15
4
4
2
2
1
1
Host
Rabbit
626
20
Clonality
Polyclonal
Conjugate
Un-conjugated
23
20
20
20
20
20
20
12
11
10
10
10
10
10
4
2
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
369
238
198
134
130
110
28
25
18
13
12
5
3
3
1
Options
Immunogen Recombinant protein of human IRS1
Isotype IgG
Purification Affinity purification
Antigen
Alternative Name IRS1 (IRS1 Antibody Abstract)
Background

Synonyms: HIRS 1,HIRS1,Insulin receptor substrate 1,IRS 1,IRS-1,IRS1,IRS1,OTTHUMP00000164234

Background: This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.

Molecular Weight

Observed_MW: 210kDa

Calculated_MW: 131kDa

Gene ID 3667
UniProt P35568
Pathways Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Negative Regulation of Hormone Secretion, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process
Application Notes WB 1:500 - 1:1000 IHC 1:50 - 1:100
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze / thaw cycles.
Supplier Images
Image no. 1 for anti-Insulin Receptor Substrate 1 (IRS1) antibody (ABIN6566530) Western blot analysis of extracts of HepG2 cells, using IRS1 antibody.
Image no. 2 for anti-Insulin Receptor Substrate 1 (IRS1) antibody (ABIN6566530) Immunohistochemistry of paraffin-embedded human gastric cancer using IRS1 antibody.
Image no. 3 for anti-Insulin Receptor Substrate 1 (IRS1) antibody (ABIN6566530) Immunohistochemistry of paraffin-embedded human stomach using IRS1 antibody.