Synonyms: CIMT1,GLM1,NR1C3,Nuclear receptor subfamily 1 group C member 3,OTTHUMP00000185032,OTTHUMP00000185036,Peroxisome proliferator activated nuclear receptor gamma variant 1,Peroxisome proliferator activated receptor gamma 1,Peroxisome Proliferator Activated Receptor gamma,Peroxisome proliferator-activated receptor gamma,PPAR gamma,PPAR-gamma,PPARG,PPARG,PPARG1,PPARG2,PPARgamma
Background: This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described.