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ABL1 antibody

ABL1 Reactivity: Human, Rat WB, IHC, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6566560
  • Target See all ABL1 Antibodies
    ABL1 (C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1))
    Reactivity
    • 256
    • 142
    • 107
    • 14
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Rat
    Host
    • 340
    • 2
    Rabbit
    Clonality
    • 340
    • 2
    Polyclonal
    Conjugate
    • 112
    • 25
    • 23
    • 21
    • 14
    • 14
    • 14
    • 14
    • 14
    • 14
    • 11
    • 11
    • 11
    • 11
    • 11
    • 11
    • 11
    This ABL1 antibody is un-conjugated
    Application
    • 224
    • 143
    • 143
    • 142
    • 77
    • 58
    • 33
    • 33
    • 28
    • 17
    • 10
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
    Purification
    Affinity purification
    Immunogen
    A synthetic peptide of human ABL1 (NP_005148.2).
    Isotype
    IgG
    Top Product
    Discover our top product ABL1 Primary Antibody
  • Application Notes
    WB 1:500-1:2000 IHC 1:100-1:200 IF 1:50-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    ABL1 (C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1))
    Alternative Name
    ABL1 (ABL1 Products)
    Synonyms
    ABL antibody, JTK7 antibody, bcr/abl antibody, c-ABL antibody, p150 antibody, v-abl antibody, AI325092 antibody, Abl antibody, E430008G22Rik antibody, c-Abl antibody, ABL proto-oncogene 1, non-receptor tyrosine kinase antibody, c-abl oncogene 1, non-receptor tyrosine kinase antibody, Tyrosine-protein kinase abl-1 antibody, ABL1 antibody, Abl1 antibody, abl-1 antibody, abl1 antibody
    Background
    This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9,22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR, MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons.
    Molecular Weight

    Observed_MW: 139kDa

    Calculated_MW: 122kDa/124kDa

    Gene ID
    25
    UniProt
    P00519
    Pathways
    Apoptosis, Regulation of Muscle Cell Differentiation, Platelet-derived growth Factor Receptor Signaling, Lipid Metabolism
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