CDK4 antibody (Cyclin-Dependent Kinase 4)

Details for Product anti-CDK4 Antibody No. ABIN6566583
Antigen
Reactivity
Human, Mouse (Murine), Rat (Rattus)
260
127
103
20
9
6
6
5
5
1
1
1
Host
Rabbit
194
94
4
2
1
Clonality
Polyclonal
Conjugate
This CDK4 antibody is un-conjugated
17
12
8
5
5
5
5
5
5
5
5
4
2
2
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
239
102
64
49
43
30
24
14
13
8
6
6
5
4
2
2
2
1
Options
Immunogen Recombinant protein of human CDK4
Isotype IgG
Purification Affinity purification
Antigen
Alternative Name CDK4 (CDK4 Antibody Abstract)
Background

Synonyms: Cdk 4,cdk4,CDK4 protein,CDK4,Cell division kinase 4,Cell division protein kinase 4,CMM 3,CMM3,Crk3,Cyclin dependent kinase 4,Cyclin-dependent kinase 4,Melanoma cutaneous malignant 3,MGC14458,p34 cdk4,PSK J3,PSK-J3

Background: The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.

Molecular Weight

Observed_MW: 32kDa

Calculated_MW: 20kDa/33kDa

Gene ID 1019
UniProt P11802
Pathways Cell Division Cycle, Mitotic G1-G1/S Phases, Regulation of Cell Size
Application Notes WB 1:500 - 1:2000 IHC 1:50 - 1:200
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze / thaw cycles.
Supplier Images
Image no. 1 for anti-Cyclin-Dependent Kinase 4 (CDK4) antibody (ABIN6566583) Western blot analysis of extracts of various cell lines, using CDK4 antibody.
Image no. 2 for anti-Cyclin-Dependent Kinase 4 (CDK4) antibody (ABIN6566583) Immunohistochemistry of paraffin-embedded rat kidney using CDK4 Antibody.