Synonyms: A1A1,AT1A1,AT1A1,ATP1A1,Atpa-1,ATPase Na+/K+ transporting alpha 1 polypeptide,ATPase Na+/K+ transporting subunit alpha 1,BC010319,EC 126.96.36.199,MGC3285,MGC38419,MGC51750,Na K ATPase alpha A catalytic polypeptide,Na K ATPase catalytic subunit alpha A protein,Na(+)/K(+) ATPase 1,Na(+)/K(+) ATPase alpha-1 subunit,Na+,K+ ATPase alpha subunit,Na+/K+ ATPase alpha 1 subunit,Na+/K+ ATPase 1,Na,K ATPase alpha 1 subunit,Nkaa1b,Sodium potassium ATPase alpha 1 polypeptide,Sodium pump 1,Sodium pump subunit alpha-1,sodium-potassium ATPase catalytic subunit alpha-1,Sodium/potassium-transporting ATPase subunit alpha-1
Background: The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene.