Synonyms: CTLA 8,CTLA-8,CTLA8,Cytotoxic T lymphocyte associated antigen 8,Cytotoxic T lymphocyte associated protein 8,Cytotoxic T lymphocyte associated serine esterase 8,Cytotoxic T-lymphocyte-associated antigen 8,IL 17A,IL-17,IL-17A,IL17,IL17,Il17a,Interleukin 17 (cytotoxic T lymphocyte associated serine esterase 8),Interleukin 17A,Interleukin-17A,Interleukin17,Interleukin17A,OTTHUMP00000016597,OTTMUSP00000046003
Background: The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.