P4HB antibody

Catalog No. ABIN6566647

Product Details anti-P4HB Antibody

Target: P4HB (Prolyl 4-Hydroxylase, beta Polypeptide (P4HB))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This P4HB antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF)

Purification: Affinity purification

Immunogen: Recombinant protein of human P4HB

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000 IF 1:20 - 1:100 IP 1:50 - 1:100

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for P4HB

Target: P4HB (Prolyl 4-Hydroxylase, beta Polypeptide (P4HB))

Alternative Name: P4HB (P4HB Products)

Synonyms: DSI antibody, ERBA2L antibody, GIT antibody, P4Hbeta antibody, PDI antibody, PDIA1 antibody, PHDB antibody, PO4DB antibody, PO4HB antibody, PROHB antibody, PDA2 antibody, PDIP antibody, PDIR antibody, ERp59 antibody, Pdia1 antibody, Thbp antibody, p55 antibody, XPDIp antibody, pdi antibody, 1810041F13Rik antibody, AI661267 antibody, Pdip antibody, Pdipl antibody, p58 antibody, prolyl 4-hydroxylase subunit beta antibody, protein disulfide isomerase family A member 2 antibody, prolyl 4-hydroxylase, beta polypeptide antibody, protein disulfide isomerase family A member 2 L homeolog antibody, protein disulfide isomerase associated 2 antibody, prolyl 4-hydroxylase subunit beta L homeolog antibody, protein disulfide-isomerase antibody, P4HB antibody, PDIA2 antibody, P4hb antibody, pdia2.L antibody, Pdia2 antibody, p4hb.L antibody, LOC8281065 antibody

Background:

Synonyms: Cellular thyroid hormone binding protein,Cellular thyroid hormone-binding protein,Collagen prolyl 4 hydroxylase beta,Disulphide Isomerase,DSI,EC 5.3.4.1,Endoplasmic reticulum resident protein 59,ER protein 59,ERBA2L,ERp59,GIT,Gltathione insulin transhydrogenase,Glutathione insulin transhydrogenase,P4HB,P4Hbeta,p55,PDI,PDIA1,PDIA1,PDIR,PHDB,PO4DB,PO4HB,Procollagen proline 2 oxoglutarate 4 dioxygenase (proline 4 hydroxylase) beta polypeptide (protein disulfide isomerase associated 1),Procollagen proline 2 oxoglutarate 4 dioxygenase beta subunit,PROHB,Prolyl 4 hydroxylase beta polypeptide,Prolyl 4 hydroxylase beta subunit,Prolyl 4 hydroxylase subunit beta,Prolyl 4-hydroxylase subunit beta,Protein disulfide isomerase associated 1,Protein disulfide isomerase,family A,member 1,Protein disulfide isomerase/oxidoreductase,Protein disulfide-isomerase,Protocollagen hydroxylase,Thbp,Thyroid hormone binding protein p55,Thyroid hormone binding protein p55 cellular,V erb a avian erythroblastic leukemia viral oncogene homolog 2 like

Background: This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex.

Molecular Weight:

Observed_MW: 57kDa

Calculated_MW: 57kDa

Gene ID: 5034

UniProt: P07237

Pathways: Maintenance of Protein Location, Cell RedoxHomeostasis, Lipid Metabolism