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Synonyms: IIAE7,Interferon regulatory factor 3,IRF 3,IRF-3,IRF3,IRF3,MGC94729
Background: This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Observed_MW: 47kDa, 55kDa