TRAF3 antibody (TNF Receptor-Associated Factor 3)

Details for Product anti-TRAF3 Antibody No. ABIN6566684
Antigen
Reactivity
Human, Mouse (Murine), Rat (Rattus)
143
88
51
4
4
2
1
1
1
1
1
1
1
1
Host
Rabbit
134
11
Clonality
Polyclonal
Conjugate
This TRAF3 antibody is un-conjugated
6
4
4
3
3
3
3
3
3
3
2
2
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
117
54
24
20
16
13
13
11
8
5
4
3
2
2
1
Options
Immunogen A synthetic peptide of human TRAF3
Isotype IgG
Purification Affinity purification
Antigen
Alternative Name TRAF3 (TRAF3 Antibody Abstract)
Background

Synonyms: CAP 1,CAP-1,CAP1,CD40 associated protein 1,CD40 binding protein,CD40 bp,CD40 receptor associated factor 1,CD40 receptor-associated factor 1,CD40-binding protein,CD40BP,CRAF 1,CRAF1,IIAE5,LAP 1,LAP1,LMP1 associated protein,LMP1-associated protein 1,MIPT3,TNF receptor associated factor 3,TNF receptor-associated factor 3,TRAF 3,Traf3,TRAF3

Background: The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Several alternatively spliced transcript variants encoding three distinct isoforms have been reported.

Molecular Weight

Observed_MW: 70kDa

Calculated_MW: 55kDa/64kDa

Gene ID 7187
UniProt Q13114
Pathways NF-kappaB Signaling, Apoptosis, TLR Signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades
Application Notes WB 1:200 - 1:1000 IHC 1:50 - 1:200
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze / thaw cycles.
Supplier Images
Image no. 1 for anti-TNF Receptor-Associated Factor 3 (TRAF3) antibody (ABIN6566684) Immunohistochemistry of paraffin-embedded human stomach using TRAF3 antibody.
Image no. 2 for anti-TNF Receptor-Associated Factor 3 (TRAF3) antibody (ABIN6566684) Western blot analysis of extracts of various cell lines, using TRAF3 antibody.