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PRKAR1A antibody

PRKAR1A Reactivity: Human WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6566690
  • Target See all PRKAR1A Antibodies
    PRKAR1A (Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) (PRKAR1A))
    Reactivity
    • 47
    • 18
    • 16
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 43
    • 4
    Rabbit
    Clonality
    • 44
    • 3
    Polyclonal
    Conjugate
    • 30
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PRKAR1A antibody is un-conjugated
    Application
    • 40
    • 18
    • 17
    • 6
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Purification
    Affinity purification
    Immunogen
    Recombinant protein of human PRKAR1A
    Isotype
    IgG
    Top Product
    Discover our top product PRKAR1A Primary Antibody
  • Application Notes
    WB 1:500 - 1:2000 IHC 1:50 - 1:200
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    PRKAR1A (Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) (PRKAR1A))
    Alternative Name
    PRKAR1A (PRKAR1A Products)
    Synonyms
    ACRDYS1 antibody, ADOHR antibody, CAR antibody, CNC antibody, CNC1 antibody, PKR1 antibody, PPNAD1 antibody, PRKAR1 antibody, TSE1 antibody, 1300018C22Rik antibody, RIalpha antibody, Tse-1 antibody, Tse1 antibody, RIIA antibody, prkar1a antibody, zgc:92515 antibody, im:7047729 antibody, cnc1 antibody, pkr1 antibody, ppnad1 antibody, prkar1 antibody, tse1 antibody, protein kinase cAMP-dependent type I regulatory subunit alpha antibody, protein kinase, cAMP dependent regulatory, type I, alpha antibody, protein kinase cAMP-dependent type 1 regulatory subunit alpha antibody, protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) a antibody, cAMP-dependent protein kinase type I-alpha regulatory subunit pseudogene antibody, protein kinase cAMP-dependent type I regulatory subunit alpha S homeolog antibody, PRKAR1A antibody, Prkar1a antibody, prkar1aa antibody, LOC707275 antibody, prkar1a.S antibody
    Background

    Synonyms: ACRDYS1,ADOHR,cAMP dependent protein kinase regulatory subunit alpha 1,cAMP dependent protein kinase regulatory subunit RIalpha,cAMP dependent protein kinase type I alpha regulatory chain,cAMP dependent protein kinase type I alpha regulatory subunit,cAMP-dependent protein kinase type I-alpha regulatory subunit,CAR,Carney complex type 1,CNC 1,CNC,CNC1,DKFZp779L0468,KAP0,MGC17251,PKA RIA,PKR 1,PKR1,PPNAD 1,PPNAD1,PRKAR 1,PRKAR1,PRKAR1A,PRKAR1A/RARA FUSION GENE,Protein kinase A type 1a regulatory subunit,Protein kinase cAMP dependent regulatory type I alpha,PTC2 CHIMERIC ONCOGENE,INCLUDED,Tissue specific extinguisher 1,Tissue-specific extinguisher 1,TSE 1,TSE1

    Background: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed.

    Molecular Weight

    Observed_MW: 45kDa

    Calculated_MW: 38kDa/42kDa

    Gene ID
    5573
    UniProt
    P10644
    Pathways
    Hedgehog Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Myometrial Relaxation and Contraction, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma
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