E3 Ubiquitin-Protein Ligase Parkin (PRKN) antibody

Details for Product No. ABIN6566709
Antigen
Reactivity
Human, Mouse (Murine), Rat (Rattus)
1
1
Host
Rabbit
1
Clonality
Polyclonal
Application
Immunofluorescence (IF), Western Blotting (WB)
1
1
Options
Immunogen Recombinant protein of human PARK2
Isotype IgG
Purification Affinity purification
Antigen
Alternative Name PRKN
Background

Synonyms: AR JP,E3 ubiquitin ligase,E3 ubiquitin protein ligase parkin,E3 ubiquitin-protein ligase parkin,FRA6E,LPRS 2,LPRS2,PARK 2,Park2,Parkin 2,Parkinson disease (autosomal recessive juvenile) 2,Parkinson disease (autosomal recessive,juvenile) 2,parkin,Parkinson disease protein 2,Parkinson juvenile disease protein 2,Parkinson protein 2 E3 ubiquitin protein ligase,Parkinson protein 2,E3 ubiquitin protein ligase (parkin),PDJ,PRKN 2,PRKN,PRKN2,PRKN2,Ubiquitin E3 ligase PRKN

Background: The precise function of this gene is unknown, however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support.

Molecular Weight

Observed_MW: 52kDa

Calculated_MW: 23kDa/30-51kDa

Gene ID 5071
UniProt O60260
Application Notes WB 1:500 - 1:2000 IF 1:50 - 1:200
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze / thaw cycles.
Supplier Images
Image no. 1 for anti-E3 Ubiquitin-Protein Ligase Parkin (PRKN) antibody (ABIN6566709) Immunofluorescence analysis of HeLa cells using PARK2 antibody.
Image no. 2 for anti-E3 Ubiquitin-Protein Ligase Parkin (PRKN) antibody (ABIN6566709) Western blot analysis of extracts of various cell lines, using PARK2 antibody.