UDP Glucuronosyltransferase 1 Family, Polypeptide A6 (UGT1A6) antibody

Details for Product No. ABIN6566750
Antigen
Reactivity
Human, Mouse (Murine)
32
7
5
2
2
2
2
2
1
1
1
1
1
1
Host
Rabbit
29
3
Clonality
Polyclonal
Conjugate
Un-conjugated
2
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
15
14
8
2
1
1
Options
Immunogen Recombinant protein of human UGT1A6
Isotype IgG
Purification Affinity purification
Antigen
Alternative Name UGT1A6 (UGT1A6 Antibody Abstract)
Background

Synonyms: GNT1,HLUGP,HLUGP1,Phenol metabolizing UDP glucuronosyltransferase,Phenol-metabolizing UDP-glucuronosyltransferase,UD16,UDP glucuronosyltransferase 1 family polypeptide A6,UDP glucuronosyltransferase 1A6,UDP glycosyltransferase 1 family polypeptide A6,UDP-glucuronosyltransferase 1-6,UDP-glucuronosyltransferase 1-F,UDP-glucuronosyltransferase 1A6,UDPGT,UDPGT 1-6,UGT 1F,UGT-1F,UGT1,UGT1 06,UGT1*6,UGT1-06,UGT1.6,UGT1A6,UGT1A6S,UGT1F

Background: This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing in the unique 5' end of this gene results in two transcript variants.

Molecular Weight

Observed_MW: 75kDa

Calculated_MW: 29kDa/50kDa/60kDa

Gene ID 54578
UniProt P19224
Pathways Steroid Hormone Biosynthesis, Regulation of Lipid Metabolism by PPARalpha
Application Notes WB 1:500 - 1:1000 IHC 1:50 - 1:100
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze / thaw cycles.
Supplier Images
Image no. 1 for anti-UDP Glucuronosyltransferase 1 Family, Polypeptide A6 (UGT1A6) antibody (ABIN6566750) Western blot analysis of extracts of various cell lines, using UGT1A6 antibody.
Image no. 2 for anti-UDP Glucuronosyltransferase 1 Family, Polypeptide A6 (UGT1A6) antibody (ABIN6566750) Immunohistochemistry of paraffin-embedded human uterine cancer using UGT1A6 antibody.