RAD23 Homolog B (S. Cerevisiae) (RAD23B) antibody

Details for Product No. ABIN6566885
Antigen
Reactivity
Human, Mouse (Murine)
138
56
55
8
8
6
5
5
5
4
3
2
2
1
1
1
Host
Rabbit
93
37
8
Clonality
Polyclonal
Conjugate
Un-conjugated
6
4
4
3
3
3
3
3
3
2
2
2
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
109
49
39
24
19
13
11
6
3
3
2
2
2
1
Options
Immunogen A synthetic peptide of human RAD23B
Isotype IgG
Purification Affinity purification
Antigen
Alternative Name RAD23B (RAD23B Antibody Abstract)
Background

Synonyms: hHR 23b,hHR23B,HR 23B,HR23B,mHR 23B,mHR23B,p58,RAD 23B,RAD23 (S. cerevisiae) homolog B,RAD23 homolog B (S. cerevisiae),RAD23 homolog B,RAD23 yeast homolog of B,Rad23b,RD23B,UV excision repair protein RAD23 homolog B,XP C repair complementing complex 58 kDa,XP C repair complementing complex 58 kDa protein,XP C repair complementing protein,XP-C repair-complementing complex 58 kDa protein,XPC repair complementing complex 58 kDa,XPC repair complementing complex 58 kDa protein,XPC repair complementing protein

Background: The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Molecular Weight

Observed_MW: 60kDa

Calculated_MW: 35kDa/43kDa

Gene ID 5887
UniProt P54727
Pathways DNA Damage Repair
Application Notes WB 1:500 - 1:2000 IHC 1:100 - 1:200
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze / thaw cycles.
Supplier Images
Image no. 1 for anti-RAD23 Homolog B (S. Cerevisiae) (RAD23B) antibody (ABIN6566885) Western blot analysis of extracts of various cell lines, using RAD23B antibody.
Image no. 2 for anti-RAD23 Homolog B (S. Cerevisiae) (RAD23B) antibody (ABIN6566885) Immunohistochemistry of paraffin-embedded human prostate using RAD23B antibody.
Image no. 3 for anti-RAD23 Homolog B (S. Cerevisiae) (RAD23B) antibody (ABIN6566885) Immunohistochemistry of paraffin-embedded human liver injury using RAD23B antibody.