Synonyms: hHR 23b,hHR23B,HR 23B,HR23B,mHR 23B,mHR23B,p58,RAD 23B,RAD23 (S. cerevisiae) homolog B,RAD23 homolog B (S. cerevisiae),RAD23 homolog B,RAD23 yeast homolog of B,Rad23b,RD23B,UV excision repair protein RAD23 homolog B,XP C repair complementing complex 58 kDa,XP C repair complementing complex 58 kDa protein,XP C repair complementing protein,XP-C repair-complementing complex 58 kDa protein,XPC repair complementing complex 58 kDa,XPC repair complementing complex 58 kDa protein,XPC repair complementing protein
Background: The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms.