Thymidylate Synthetase (TYMS) antibody

Details for Product No. ABIN6566932
Antigen
Reactivity
Human, Mouse (Murine)
256
28
26
3
2
2
2
2
1
1
1
Host
Rabbit
181
64
11
Clonality
Polyclonal
Conjugate
Un-conjugated
10
4
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
1
1
1
Application
Western Blotting (WB)
141
132
106
90
66
58
51
48
46
14
10
9
7
5
3
3
2
1
Options
Immunogen Recombinant protein of human TYMS
Isotype IgG
Purification Affinity purification
Antigen
Alternative Name TYMS (TYMS Antibody Abstract)
Background

Synonyms: d TMP synthase,EC 2.1.1.45 ,HsT422,MGC88736,OTTHUMP00000162195,Thymidylate synthase,Thymidylate synthetase,TMS,TS,TSase,Tyms,TYMS protein,Tyms thymidylate synthetase ,TYSY

Background: Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase.

Molecular Weight

Observed_MW: 36kDa

Calculated_MW: 26kDa/31kDa/35kDa

Gene ID 7298
UniProt P04818
Pathways Mitotic G1-G1/S Phases
Application Notes WB 1:500 - 1:2000
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze / thaw cycles.
Supplier Images
Image no. 1 for anti-Thymidylate Synthetase (TYMS) antibody (ABIN6566932) Western blot analysis of extracts of various cell lines, using TYMS antibody.