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Synonyms: d TMP synthase,EC 22.214.171.124 ,HsT422,MGC88736,OTTHUMP00000162195,Thymidylate synthase,Thymidylate synthetase,TMS,TS,TSase,Tyms,TYMS protein,Tyms thymidylate synthetase ,TYSY
Background: Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase.