P2RX7 antibody (Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7)

Details for Product anti-P2RX7 Antibody No. ABIN6566964
Antigen
Reactivity
Human, Mouse (Murine), Rat (Rattus)
89
56
35
4
4
3
3
3
2
2
Host
Rabbit
81
10
8
3
Clonality
Polyclonal
Conjugate
This P2RX7 antibody is un-conjugated
9
5
4
3
3
3
3
3
2
2
2
2
1
1
1
1
1
Application
Western Blotting (WB)
66
44
37
14
13
13
8
6
1
1
Options
Immunogen Recombinant protein of human P2RX7
Isotype IgG
Purification Affinity purification
Antigen
Alternative Name P2RX7 (P2RX7 Antibody Abstract)
Background

Synonyms: ATP receptor,P2rx7,P2RX7,P2X purinoceptor 7,P2X7,P2Z receptor,Purinergic receptor,purinergic receptor P2X, ligand gated ion channel, 7

Background: The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria.

Molecular Weight

Observed_MW: 65kDa

Calculated_MW: 14kDa/31kDa/35kDa/41kDa/49kDa/58kDa/68kDa

Gene ID 5027
UniProt Q99572
Pathways Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Synaptic Vesicle Exocytosis
Application Notes WB 1:1000 - 1:2000
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze / thaw cycles.
Supplier Images
Image no. 1 for anti-Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7) antibody (ABIN6566964) Western blot analysis of extracts of various cell lines, using P2RX7 antibody.