Synonyms: ATP receptor,P2rx7,P2RX7,P2X purinoceptor 7,P2X7,P2Z receptor,Purinergic receptor,purinergic receptor P2X, ligand gated ion channel, 7
Background: The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria.