Synonyms: FEX,G protein coupled receptor 49,G protein coupled receptor 67,g protein-coupled receptor fex,G-protein coupled receptor 49,G-protein coupled receptor 67,G-protein coupled receptor HG38,GPR 49,GPR 67,GPR49,GPR67,GRP 49,GRP49,HG 38,HG38,Leucine rich repeat containing G protein coupled receptor 5,Leucine-rich repeat-containing G-protein coupled receptor 5,LGR 5,LGR5,LGR5,MGC117008,Orphan G protein coupled receptor HG38
Background: The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene.