Minichromosome Maintenance Complex Component 2 (MCM2) antibody

Details for Product No. ABIN6566984
Antigen
Reactivity
Human, Mouse (Murine), Rat (Rattus)
207
98
59
11
11
10
9
7
5
3
3
2
2
1
1
Host
Rabbit
168
60
2
1
Clonality
Polyclonal
Conjugate
Un-conjugated
10
8
8
4
4
4
3
3
3
3
3
3
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
192
104
88
57
34
18
17
15
13
6
4
4
4
3
2
Options
Immunogen Recombinant protein of human MCM2
Isotype IgG
Purification Affinity purification
Antigen
Alternative Name MCM2 (MCM2 Antibody Abstract)
Background

Synonyms: BM28,CCNL 1,CCNL1,CDC like 1,cdc19,CDCL 1,CDCL1,Cell devision cycle like 1,Cyclin like 1,D3S3194,DNA replication licensing factor MCM2,KIAA0030,MCM 2,MCM2,MCM2 minichromosome maintenance deficient 2 mitotin,MCM2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae),MCM2 minichromosome maintenance deficient 2,mitotin,MCM2,MGC10606,Minichromosome maintenance complex component 2,Minichromosome maintenance deficient 2 (mitotin),Minichromosome maintenance deficient 2 mitotin,Minichromosome maintenance protein 2,Minichromosome maintenance protein 2 homolog,Mitotin,Nuclear protein BM28,OTTHUMP00000216047,OTTHUMP00000216050

Background: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined.

Molecular Weight

Observed_MW: 130kDa

Calculated_MW: 101kDa

Gene ID 4171
UniProt P49736
Pathways DNA Damage Repair, Mitotic G1-G1/S Phases, DNA Replication, Chromatin Binding, Synthesis of DNA
Application Notes WB 1:500 - 1:2000 IHC 1:100 - 1:200
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze / thaw cycles.
Supplier Images
Image no. 1 for anti-Minichromosome Maintenance Complex Component 2 (MCM2) antibody (ABIN6566984) Western blot analysis of extracts of various cell lines, using MCM2 antibody.
Image no. 2 for anti-Minichromosome Maintenance Complex Component 2 (MCM2) antibody (ABIN6566984) Immunohistochemistry of paraffin-embedded human colon using MCM2 antibody.