MYH11 antibody (Myosin Heavy Chain 11, Smooth Muscle)

Details for Product anti-MYH11 Antibody No. ABIN6567033
Antigen
Reactivity
Human, Mouse (Murine), Rat (Rattus)
85
48
14
13
13
13
13
13
13
12
1
Host
Rabbit
44
44
Clonality
Polyclonal
Conjugate
This MYH11 antibody is un-conjugated
2
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
36
35
28
28
27
24
12
5
5
3
3
3
3
1
1
Options
Immunogen Recombinant protein of human MYH11
Isotype IgG
Purification Affinity purification
Antigen
Alternative Name MYH11 (MYH11 Antibody Abstract)
Background

Synonyms: AAT4,DKFZp686D10126,DKFZp686D19237,FAA4,FLJ35232,MGC126726,MGC32963,MYH 11,MYH11,MYH11,Myosin 11,Myosin heavy chain 11,Myosin heavy chain 11 smooth muscle,Myosin heavy chain,Myosin heavy chain smooth muscle isoform,Myosin heavy polypeptide 11 smooth muscle,Myosin-11,SMHC,SMMHC,smooth muscle isoform,Smooth muscle myosin heavy chain 11 isoform SM2,Smooth muscle myosin heavy chain isoform SM2

Background: The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Alternatively spliced transcript variants encoding different isoforms have been identified.

Molecular Weight

Observed_MW: 250kDa

Calculated_MW: 223kDa/224kDa/227kDa/228kDa

Gene ID 4629
UniProt P35749
Application Notes WB 1:500 - 1:2000
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze / thaw cycles.
Supplier Images
Image no. 1 for anti-Myosin Heavy Chain 11, Smooth Muscle (MYH11) antibody (ABIN6567033) Western blot analysis of extracts of various cell lines, using MYH11 antibody.