BRCA1 antibody (Breast Cancer 1)

Details for Product anti-BRCA1 Antibody No. ABIN6567052
Antigen
Reactivity
Human, Mouse (Murine)
460
55
37
4
2
1
1
1
Host
Rabbit
368
101
4
3
Clonality
Polyclonal
Conjugate
This BRCA1 antibody is un-conjugated
23
12
9
9
9
9
9
9
9
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
Application
Western Blotting (WB)
270
148
142
91
71
54
46
42
23
18
16
11
6
6
4
3
2
2
Options
Immunogen Recombinant protein of human BRCA1
Isotype IgG
Purification Affinity purification
Antigen
Alternative Name BRCA1 (BRCA1 Antibody Abstract)
Background

Synonyms: BRCA 1,BRCA1,BRCA1 DNA repair associated,BRCA1/BRCA2 containing complex subunit 1,BRCA1/BRCA2-containing complex,subunit 1,BRCA1,BRCAI,BRCC 1,BRCC1,Breast and ovarian cancer susceptibility protein 1,Breast Cancer 1,Breast Cancer 1 Early Onset,Breast cancer type 1 susceptibility protein,BROVCA1,FANCS,IRIS,PNCA4,PPP1R53,Protein phosphatase 1 regulatory subunit 53,PSCP,RING finger protein 53,RNF53

Background: This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40 % of inherited breast cancers and more than 80 % of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.

Molecular Weight

Observed_MW: 280kDa

Calculated_MW: 7kDa/78-85kDa/202-210kDa

Gene ID 672
UniProt P38398
Pathways Cell Division Cycle, DNA Damage Repair, Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Response to DNA Damage Stimulus
Application Notes WB 1:500 - 1:2000
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze / thaw cycles.
Supplier Images
Image no. 1 for anti-Breast Cancer 1 (BRCA1) antibody (ABIN6567052) Western blot analysis of extracts of various cell lines, using BRCA1 antibody.