Synonyms: Bag 1,BAG family molecular chaperone regulator 1,BAG-1,BAG1,BAG1,BCL 2 Associated Athanogene 1,BCL 2 associated athanogene,BCL 2 binding athanogene 1,Bcl-2-associated athanogene 1,BCL2 associated athanogene 1,BCL2 associated athanogene,Glucocorticoid receptor-associated protein RAP46,HAP1,Haptoglobin,RAP 46,RAP46
Background: The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. Multiple protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) initiation codon, and three alternative downstream AUG initiation codons. A related pseudogene has been defined on chromosome X.