NFKBIA antibody (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha)

Details for Product anti-NFKBIA Antibody No. ABIN6567073
Antigen
Reactivity
Human, Mouse (Murine)
477
300
244
31
24
20
19
9
2
2
2
1
1
Host
Rabbit
421
61
7
7
Clonality
Polyclonal
Conjugate
This NFKBIA antibody is un-conjugated
27
13
13
13
13
13
13
12
10
6
6
6
3
3
3
3
3
Application
Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
356
183
155
78
75
60
41
28
19
18
14
4
4
3
3
3
1
1
1
Options
Immunogen Recombinant protein of human NFKBIA
Isotype IgG
Purification Affinity purification
Antigen
Alternative Name IkB alpha (NFKBIA Antibody Abstract)
Background

Synonyms: I kappa B alpha,I-kappa-B-alpha,IkappaBalpha,IkB-alpha,IKBA,IKBA,IKBalpha,MAD 3,MAD3,Major histocompatibility complex enhancer-binding protein MAD3,NF kappa B inhibitor alpha,NF-kappa-B inhibitor alpha,NFKBI,NFKBIA,Nuclear factor of kappa light chain gene enhancer in B cells,Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor alpha

Background: This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.

Molecular Weight

Observed_MW: 32kDa

Calculated_MW: 35kDa

Gene ID 4792
UniProt P25963
Pathways NF-kappaB Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Maintenance of Protein Location, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades
Application Notes WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:20 - 1:100
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze / thaw cycles.
Supplier Images
Image no. 1 for anti-Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA) antibody (ABIN6567073) Western blot analysis of extracts of various cell lines, using NFKBIA antibody.
Image no. 2 for anti-Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA) antibody (ABIN6567073) Immunohistochemistry of paraffin-embedded mouse kidney using NFKBIA antibody.
Image no. 3 for anti-Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA) antibody (ABIN6567073) Immunofluorescence analysis of HeLa cells using NFKBIA antibody.