NTAN1 antibody

Catalog No. ABIN6568757

Product Details anti-NTAN1 Antibody

Target: NTAN1 (N-terminal Asparagine Amidase (NTAN1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NTAN1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogen: Recombinant protein of human NTAN1

Isotype: IgG

Application Details

Application Notes: WB 1:200 - 1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for NTAN1

Target: NTAN1 (N-terminal Asparagine Amidase (NTAN1))

Alternative Name: NTAN1 (NTAN1 Products)

Synonyms: PNAA antibody, PNAD antibody, N-terminal Asn amidase antibody, N-terminal asparagine amidase antibody, Ntan1 antibody, NTAN1 antibody

Background:

Synonyms: N terminal Asn amidase,N terminal asparagine amidase ,N terminal asparagine amidohydrolase,NTN-amidase,PNAA ,PNAD ,Protein N-terminal Asn amidase,Protein N-terminal asparagine amidase,Protein N-terminal asparagine amidohydrolase,Protein NH2-terminal asparagine amidohydrolase,Protein NH2-terminal asparagine deamidase,Protein NTN-amidase

Background: The protein encoded by this gene functions in a step-wise process of protein degradation through the N-end rule pathway. This protein acts as a tertiary destabilizing enzyme that deamidates N-terminal L-Asn residues on proteins to produce N-terminal L-Asp. L-Asp substrates are subsequently conjugated to L-Arg, which is recognized by specific E3 ubiquitin ligases and targeted to the proteasome. Pseudogenes of this gene are located on the long arms of chromosomes 8, 10 and 12. Alternative splicing results in multiple transcript variants that encode different protein isoforms.

Molecular Weight:

Observed_MW: 35kDa

Calculated_MW: 34kDa

Gene ID: 123803

UniProt: Q96AB6