Interleukin enhancer-binding factor 3 (ILF3) antibody

Catalog No. ABIN6569231

Product Details

Target: Interleukin enhancer-binding factor 3 (ILF3)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Purification: Affinity purification

Immunogen: Recombinant fusion protein of human ILF3 (NP_036350.2).

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000 IF 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details

Target: Interleukin enhancer-binding factor 3 (ILF3)

Alternative Name: ILF3 (ILF3 Products)

Synonyms: CBTF antibody, DRBF antibody, DRBP76 antibody, MMP4 antibody, MPHOSPH4 antibody, MPP4 antibody, NF-AT-90 antibody, NF110 antibody, NF110b antibody, NF90 antibody, NF90a antibody, NF90b antibody, NFAR antibody, NFAR-1 antibody, NFAR2 antibody, TCP110 antibody, TCP80 antibody, MBII-26 antibody, ilf3 antibody, wu:fb37d07 antibody, wu:fb94b02 antibody, zgc:77030 antibody, 4F.1 antibody, cbtf122 antibody, ilf3-A antibody, ubp3 antibody, ubp4 antibody, xilf3 antibody, interleukin enhancer binding factor 3 antibody, interleukin enhancer binding factor 3b antibody, interleukin enhancer binding factor 3 S homeolog antibody, ILF3 antibody, Ilf3 antibody, ilf3b antibody, ilf3.S antibody

Background: This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein (NF90, ILF3) forms a heterodimer with a 45 kDa transcription factor (NF45, ILF2) required for T-cell expression of interleukin 2. This complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Molecular Weight:

Observed_MW: 95kDa/120kDa

Calculated_MW: 74kDa/75kDa/76kDa/82kDa/95kDa

Gene ID: 3609

UniProt: Q12906

Pathways: M Phase