Bestrophin 1 antibody

Catalog No. ABIN6570086

Product Details anti-Bestrophin 1 Antibody

Target: Bestrophin 1 (BEST1)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Bestrophin 1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogen: Recombinant protein of human BEST1

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Bestrophin 1

Target: Bestrophin 1 (BEST1)

Alternative Name: BEST1 (BEST1 Products)

Synonyms: CG6264 antibody, Dbest antibody, Dmel\\CG6264 antibody, anon-WO0118547.380 antibody, best antibody, dBest1 antibody, dbest1 antibody, dmBest1 antibody, BEST1 antibody, VMD2 antibody, best-1 antibody, ARB antibody, BEST antibody, BMD antibody, RP50 antibody, TU15B antibody, Bmd antibody, Vmd2 antibody, mBest1 antibody, Bestrophin 1 antibody, bestrophin 1 antibody, Best1 antibody, BEST1 antibody, best1 antibody, Bm1_25500 antibody

Background:

Synonyms: ARB,BEST 1,BEST,Best disease,Best macular dystrophy,BEST1,BEST1,Best1V1Delta2,Bestrophin 1,Bestrophin-1,Bestrophin1,BMD,mBest1,RP50,TU15B,Vitelliform macular dystrophy 2,Vitelliform macular dystrophy,Vitelliform macular dystrophy protein 2,VMD 2,VMD2

Background: This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.

Molecular Weight:

Observed_MW: 70kDa

Calculated_MW: 57kDa/67kDa/69kDa

Gene ID: 7439

UniProt: O76090