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Aconitase 1 antibody

ACO1 Reactivity: Human, Mouse, Rat IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6571416
  • Target See all Aconitase 1 (ACO1) Antibodies
    Aconitase 1 (ACO1)
    Reactivity
    • 101
    • 45
    • 40
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 105
    • 3
    • 1
    Rabbit
    Clonality
    • 107
    • 2
    Polyclonal
    Conjugate
    • 51
    • 12
    • 8
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    This Aconitase 1 antibody is un-conjugated
    Application
    • 95
    • 39
    • 34
    • 27
    • 26
    • 20
    • 11
    • 11
    • 9
    • 4
    • 3
    • 2
    Immunohistochemistry (IHC)
    Purification
    Affinity purification
    Immunogen
    Recombinant fusion protein of human ACO1 (NP_002188.1).
    Isotype
    IgG
    Top Product
    Discover our top product ACO1 Primary Antibody
  • Application Notes
    IHC 1:50-1:100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    Aconitase 1 (ACO1)
    Alternative Name
    ACO1 (ACO1 Products)
    Synonyms
    ACONS antibody, IREB1 antibody, IREBP antibody, IREBP1 antibody, IRP1 antibody, Acon1 antibody, Ratireb antibody, ratireb antibody, Aco1 antibody, AI256519 antibody, Aco-1 antibody, Irebp antibody, Irp1 antibody, aconitase 1 antibody, aconitase 1, soluble antibody, aconitase 1 L homeolog antibody, ACO1 antibody, Aco1 antibody, aco1.L antibody
    Background
    The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants
    Molecular Weight

    Observed_MW: 120kDa

    Calculated_MW: 98kDa

    Gene ID
    48
    UniProt
    P21399
    Pathways
    Transition Metal Ion Homeostasis
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