AVPR2 antibody

Catalog No. ABIN6571426

Product Details anti-AVPR2 Antibody

Target: AVPR2 (Arginine Vasopressin Receptor 2 (AVPR2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AVPR2 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogen: Recombinant fusion protein of human AVPR2 (NP_000045.1).

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for AVPR2

Target: AVPR2 (Arginine Vasopressin Receptor 2 (AVPR2))

Alternative Name: AVPR2 (AVPR2 Products)

Synonyms: AVPR2 antibody, ADHR antibody, DI1 antibody, DIR antibody, DIR3 antibody, NDI antibody, V2R antibody, ND1 antibody, VPV2R antibody, arginine vasopressin receptor 2 antibody, AVPR2 antibody, Avpr2 antibody

Background: This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these 'extrarenal receptors' are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. The gene expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing.

Molecular Weight:

Observed_MW: 46kDa

Calculated_MW: 33kDa/40kDa

Gene ID: 554

UniProt: P30518

Pathways: cAMP Metabolic Process