PRSS2 antibody

Catalog No. ABIN6571458

Product Details anti-PRSS2 Antibody

Target: PRSS2 (Protease, serine, 2 (Trypsin 2) (PRSS2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRSS2 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogen: Recombinant protein of human PRSS2

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PRSS2

Target: PRSS2 (Protease, serine, 2 (Trypsin 2) (PRSS2))

Alternative Name: PRSS2 (PRSS2 Products)

Synonyms: Dvir\\GJ21501 antibody, Dvtry-2 antibody, GJ21501 antibody, Try2 antibody, dvir_GLEANR_6854 antibody, TRY8 antibody, TRYP antibody, Ta antibody, Tesp4 antibody, Ptryss2 antibody, TRY2 antibody, TRYP2 antibody, trypsin-2 antibody, Trypsin-2 antibody, protease, serine 2 antibody, protease, serine, 2 antibody, trypsin II antibody, CpipJ_CPIJ000771 antibody, CpipJ_CPIJ020109 antibody, Dvir\Try2 antibody, Prss2 antibody, PRSS2 antibody, trp-ii antibody

Background:

Synonyms: Anionic trypsinogen,EC 3.4.21.4,MGC111183,MGC120174,Protease serine 2 preproprotein ,Protease, serine, 2 (trypsin 2),Protease, serine, 2,Protease, serine, 2, preproprotein ,Prss2,Serine protease 2,TRY2,TRY2,TRY8,TRYP2,Trypsin 2,Trypsin II,Trypsin-2,Trypsinogen 2

Background: This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.

Molecular Weight:

Observed_MW: 26kDa

Calculated_MW: 26kDa

Gene ID: 5645

UniProt: P07478