APITD1 antibody

Catalog No. ABIN6571658

Product Details anti-APITD1 Antibody

Target: APITD1 (Apoptosis-Inducing, TAF9-Like Domain 1 (APITD1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APITD1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogen: Recombinant protein of human APITD1

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for APITD1

Target: APITD1 (Apoptosis-Inducing, TAF9-Like Domain 1 (APITD1))

Alternative Name: APITD1 (APITD1 Products)

Synonyms: CENP-S antibody, CENPS antibody, FAAP16 antibody, MHF1 antibody, 2610040C18Rik antibody, 2810407L01Rik antibody, cenps antibody, mhf1 antibody, APITD1 antibody, Apitd1 antibody, Mhf1 antibody, apitd1 antibody, zgc:194319 antibody, centromere protein S antibody, apoptosis-inducing, TAF9-like domain 1 antibody, centromere protein S L homeolog antibody, CENPS antibody, Cenps antibody, cenps.L antibody, APITD1 antibody, cenps antibody

Background:

Synonyms: APITD1,Apoptosis-inducing TAF9-like domain-containing protein 1,apoptosis-inducing, TAF9-like domain 1,CENP-S,CENPS,CENPS,Centromere protein S,FAAP16,FANCM-interacting histone fold protein 1,Fanconi anemia-associated polypeptide of 16 kDa,MGC32686,MHF 1

Background: This gene was identified in the neuroblastoma tumor suppressor candidate region on chromosome 1p36. It contains a TFIID-31 domain, similar to that found in TATA box-binding protein-associated factor, TAF(II)31, which is required for p53-mediated transcription activation. This gene was expressed at very low levels in neuroblastoma tumors, and was shown to reduce cell growth in neuroblastoma cells, suggesting that it may have a role in a cell death pathway. The protein is a component of multiple complexes, including the Fanconi anemia (FA) core complex, the APITD1/CENPS complex, and the CENPA-CAD (nucleosome distal) complex. Known functions include an involvement with chromatin associations of the FA core complex, and a role in the stable assembly of the outer kinetochore. Alternative splicing of this gene results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream cortistatin (CORT) gene, as represented in GeneID:100526739. An APITD1-related pseudogene has been identified on chromosome 7.

Molecular Weight:

Observed_MW: 16kDa

Calculated_MW: 9kDa/15kDa/19kDa

Gene ID: 100526739

UniProt: Q8N2Z9