SPAG8 antibody

Catalog No. ABIN6571917

Product Details anti-SPAG8 Antibody

Target: SPAG8 (Sperm Associated Antigen 8 (SPAG8))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPAG8 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogen: Recombinant protein of human SPAG8

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for SPAG8

Target: SPAG8 (Sperm Associated Antigen 8 (SPAG8))

Alternative Name: SPAG8 (SPAG8 Products)

Synonyms: BS-84 antibody, HSD-1 antibody, SMP1 antibody, SPAG3 antibody, hSMP-1 antibody, MH-SPAG8 antibody, sperm associated antigen 8 antibody, SPAG8 antibody, Spag8 antibody

Background:

Synonyms: BS 84,CILD28,HSD 1,HSD-1,HSD1,hSMP1,MGC26201,MH SPAG8,OTTHUMP00000021352,OTTMUSP00000032209,SMP-1,SMP1,SPAG3,SPAG8,SPAG8,Sperm associated antigen 8,Sperm associated antigen 8 like protein,Sperm membrane protein 1,Sperm membrane protein BS-84,Sperm-associated antigen 8,Testicular tissue protein Li 177

Background: The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein encoded by this gene is recognized by sperm agglutinating antibodies from an infertile woman. This protein is localized in germ cells of the testis at all stages of spermatogenesis and is localized to the acrosomal region of mature spermatozoa. This protein interacts with ACT (activator of CREM in testis) and may play a role in CREM (cAMP response element modulator)-ACT-mediated gene transcription during spermatogenesis. This protein may also play a role in spermatogenesis by regulating microtubule formation and cell division. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined.

Molecular Weight:

Observed_MW: 45kDa

Calculated_MW: 44kDa/51kDa/53kDa

Gene ID: 26206

UniProt: Q99932