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CBFB antibody (Internal Region)

CBFB Reactivity: Human ELISA, ChIP Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6655308
  • Target See all CBFB Antibodies
    CBFB (Core-Binding Factor, beta Subunit (CBFB))
    Binding Specificity
    • 8
    • 7
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    • 58
    • 22
    • 22
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 51
    • 7
    • 2
    • 1
    Rabbit
    Clonality
    • 48
    • 13
    Polyclonal
    Conjugate
    • 38
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    This CBFB antibody is un-conjugated
    Application
    • 38
    • 22
    • 13
    • 10
    • 10
    • 6
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    ELISA, Chromatin Immunoprecipitation (ChIP)
    Purification
    Anti-CBFb Antibody is monospecific antiserum processed by delipidation and defibrination followed by sterile filtration. This product reacts with human CBFb.  Cross reactivity with CBFb from other sources is not known.
    Immunogen

    Immunogen: Anti-CBFb Antibody was produced in rabbits by repeated immunizations with human CBFb using two synthetic peptides containing sequences from the internal region of the protein.

    Immunogen Type: Peptide

    Top Product
    Discover our top product CBFB Primary Antibody
  • Application Notes

    Application Note: Anti-CBFb Antibody is suitable for Chromatin Immunoprecipitation and ELISA. Specific conditions for reactivity should be optimized by the end user.

    ChIP Dilution: 4 μL/ChIP

    ELISA Dilution: 1:500

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer

    0.01 % (w/v) Sodium Azide

    Stabilizer: None

    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    RT,4 °C,-20 °C
    Storage Comment
    Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
  • Target
    CBFB (Core-Binding Factor, beta Subunit (CBFB))
    Alternative Name
    CBFb (CBFB Products)
    Synonyms
    PEBP2B antibody, Cbfb antibody, pebp2b antibody, Pebp2 antibody, CBFB antibody, unp1266 antibody, cbf-beta antibody, cbfbeta antibody, pea2-beta antibody, pebp2-beta antibody, AI893578 antibody, PEA2 antibody, PEBP2b antibody, Pebpb2 antibody, core-binding factor beta subunit antibody, core binding factor beta subunit antibody, core-binding factor, beta subunit antibody, core-binding factor, beta subunit S homeolog antibody, core binding factor beta antibody, CBFB antibody, Cbfb antibody, cbfb antibody, cbfb.S antibody
    Background

    Synonyms: Core-binding factor subunit beta, CBF-beta, Polyomavirus enhancer-binding protein 2 beta subunit, PEA2-beta, PEBP2-beta, SL3-3 enhancer factor 1 subunit beta, SL3/AKV core-binding factor beta subunit

    Background: CBFb represents the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family. These transcription factors regulate a host of genes specific to haematopoiesis (e.g. RUNX1) and osteogenesis (e.g. RUNX2). The beta subunit is the regulatory subunit which allosterically enhances the activity of the DNA binding alpha subunit as the complex binds to the core site of various enhancers and promoters. CBFb can be involved in a chromosomal rearrangement of chromosome 16 (inv(16)(p13q22)) which produces a fusion protein consisting of the N terminus of CBFb and the C-terminal portion of MYH11. This chromosomal rearrangement is associated with acute myeloid leukaemia of the M4Eo subtype. Anti-CBFb Antibody is ideal for research in Gene Expression, Cell Differentiation and Cancer.

    Gene Name: CBFB

    Gene ID
    12400
    NCBI Accession
    NP_001154928
    UniProt
    Q08024
    Pathways
    Regulation of Lipid Metabolism by PPARalpha
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