CBFB antibody (Internal Region)
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- Target See all CBFB Antibodies
- CBFB (Core-Binding Factor, beta Subunit (CBFB))
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Binding Specificity
- Internal Region
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This CBFB antibody is un-conjugated
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Application
- ELISA, Chromatin Immunoprecipitation (ChIP)
- Purification
- Anti-CBFb Antibody is monospecific antiserum processed by delipidation and defibrination followed by sterile filtration. This product reacts with human CBFb. Cross reactivity with CBFb from other sources is not known.
- Immunogen
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Immunogen: Anti-CBFb Antibody was produced in rabbits by repeated immunizations with human CBFb using two synthetic peptides containing sequences from the internal region of the protein.
Immunogen Type: Peptide
- Top Product
- Discover our top product CBFB Primary Antibody
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- Application Notes
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Application Note: Anti-CBFb Antibody is suitable for Chromatin Immunoprecipitation and ELISA. Specific conditions for reactivity should be optimized by the end user.
ChIP Dilution: 4 μL/ChIP
ELISA Dilution: 1:500
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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0.01 % (w/v) Sodium Azide
Stabilizer: None
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- RT,4 °C,-20 °C
- Storage Comment
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
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- Target
- CBFB (Core-Binding Factor, beta Subunit (CBFB))
- Alternative Name
- CBFb (CBFB Products)
- Synonyms
- PEBP2B antibody, Cbfb antibody, pebp2b antibody, Pebp2 antibody, CBFB antibody, unp1266 antibody, cbf-beta antibody, cbfbeta antibody, pea2-beta antibody, pebp2-beta antibody, AI893578 antibody, PEA2 antibody, PEBP2b antibody, Pebpb2 antibody, core-binding factor beta subunit antibody, core binding factor beta subunit antibody, core-binding factor, beta subunit antibody, core-binding factor, beta subunit S homeolog antibody, core binding factor beta antibody, CBFB antibody, Cbfb antibody, cbfb antibody, cbfb.S antibody
- Background
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Synonyms: Core-binding factor subunit beta, CBF-beta, Polyomavirus enhancer-binding protein 2 beta subunit, PEA2-beta, PEBP2-beta, SL3-3 enhancer factor 1 subunit beta, SL3/AKV core-binding factor beta subunit
Background: CBFb represents the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family. These transcription factors regulate a host of genes specific to haematopoiesis (e.g. RUNX1) and osteogenesis (e.g. RUNX2). The beta subunit is the regulatory subunit which allosterically enhances the activity of the DNA binding alpha subunit as the complex binds to the core site of various enhancers and promoters. CBFb can be involved in a chromosomal rearrangement of chromosome 16 (inv(16)(p13q22)) which produces a fusion protein consisting of the N terminus of CBFb and the C-terminal portion of MYH11. This chromosomal rearrangement is associated with acute myeloid leukaemia of the M4Eo subtype. Anti-CBFb Antibody is ideal for research in Gene Expression, Cell Differentiation and Cancer.
Gene Name: CBFB
- Gene ID
- 12400
- NCBI Accession
- NP_001154928
- UniProt
- Q08024
- Pathways
- Regulation of Lipid Metabolism by PPARalpha
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