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IFNB1 antibody (Interferon, beta 1, Fibroblast) (Internal Region) Primary Antibody

IFNB1 Reactivity: Human ELISA, FM, IHC, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6655800
$411.00
Plus shipping costs $45.00 and $22.00 dry ice
100 μg
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  • Target See all IFNB1 Antibodies
    IFNB1
    Binding Specificity
    • 15
    • 10
    • 9
    • 9
    • 9
    • 8
    • 6
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    • 95
    • 21
    • 19
    • 9
    • 9
    • 7
    • 6
    • 5
    • 4
    • 1
    Human
    Host
    • 107
    • 29
    • 4
    • 4
    • 1
    • 1
    Rabbit
    Clonality
    • 117
    • 28
    Polyclonal
    Conjugate
    • 77
    • 24
    • 17
    • 7
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This IFNB1 antibody is un-conjugated
    Application
    • 111
    • 68
    • 64
    • 32
    • 20
    • 15
    • 14
    • 14
    • 13
    • 7
    • 7
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    ELISA, Fluorescence Microscopy (FM), Immunohistochemistry (IHC), Western Blotting (WB)
    Cross-Reactivity
    Human, Mouse (Murine)
    Cross-Reactivity (Details)
    Cross reactivity with IFN-beta from other sources has not been determined.
    Purification
    Anti-IFN-beta Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography.
    Immunogen

    Immunogen: Anti-IFN-beta antibody was prepared from whole rabbit serum produced by repeated immunizations with a 17 amino acid synthetic peptide from near the internal region of human IFN-b.

    Immunogen Type: Peptide

    Isotype
    IgG
  • Application Notes

    Immunohistochemistry Dilution: 5 μg/mL

    Application Note: Anti-IFN-beta Antibody has been tested for use in ELISA, Western Blotting, Immunohistochemistry and Immunofluorescence. Specific conditions for reactivity should be optimized by the end user. Expect a band at approximately 22 kDa in Western Blots of specific cell lysates and tissues.

    ELISA Dilution: 1:50,000

    Western Blot Dilution: 5 μg/mL

    IF Microscopy Dilution: 20 μg/mL

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer

    Buffer: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2

    Stabilizer: None

    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    RT,4 °C,-20 °C
    Storage Comment
    Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
  • Target
    IFNB1
    Alternative Name
    IFN-beta (IFNB1 Products)
    Synonyms
    IFB, IFF, IFNB, IFN-beta, Ifb, Ifnb, IFNb, interferon beta 1, interferon beta 1, fibroblast, interferon, beta 1, fibroblast, IFNB1, Ifnb1
    Background

    Synonyms: IFN-beta Antibody, IFB, IFF, IFNB, IFB, Interferon beta, Fibroblast interferon, IFN-beta

    Background: Type I Interferons (IFN-alpha/beta) are produced primarily in response to viral infection by "Natural IFN-producing cells" (IPCs) as part of the host immune response and can also inhibit the development of tumors. IFN-beta binding by its receptor results in the activation of the tyrosine kinases Jak1 and Tyk2 and phosphorylation of members of the STAT family of transcription factors, leading to the transcription and expression of the immune response genes. More recently, several members of the toll-like receptor (TLR) family were found to stimulate the production IFN-beta. IFN-beta is currently used clinically for treatment of tumors, infections and multiple sclerosis.

    Gene Name: IFNB1

    Gene ID
    3456
    UniProt
    P01574
    Pathways
    JAK-STAT Signaling, TCR Signaling, TLR Signaling, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Autophagy, Inflammasome
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