IFNB1 antibody (Interferon, beta 1, Fibroblast) (Internal Region) Primary Antibody
- Target See all IFNB1 Antibodies
- Internal Region
- This IFNB1 antibody is un-conjugated
- ELISA, Fluorescence Microscopy (FM), Immunohistochemistry (IHC), Western Blotting (WB)
- Human, Mouse (Murine)
- Cross-Reactivity (Details)
- Cross reactivity with IFN-beta from other sources has not been determined.
- Anti-IFN-beta Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography.
Immunogen: Anti-IFN-beta antibody was prepared from whole rabbit serum produced by repeated immunizations with a 17 amino acid synthetic peptide from near the internal region of human IFN-b.
Immunogen Type: Peptide
- Application Notes
Immunohistochemistry Dilution: 5 μg/mL
Application Note: Anti-IFN-beta Antibody has been tested for use in ELISA, Western Blotting, Immunohistochemistry and Immunofluorescence. Specific conditions for reactivity should be optimized by the end user. Expect a band at approximately 22 kDa in Western Blots of specific cell lysates and tissues.
ELISA Dilution: 1:50,000
Western Blot Dilution: 5 μg/mL
IF Microscopy Dilution: 20 μg/mL
- For Research Use only
Buffer: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- RT,4 °C,-20 °C
- Storage Comment
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
- Alternative Name
- IFN-beta (IFNB1 Products)
- IFB, IFF, IFNB, IFN-beta, Ifb, Ifnb, IFNb, interferon beta 1, interferon beta 1, fibroblast, interferon, beta 1, fibroblast, IFNB1, Ifnb1
Synonyms: IFN-beta Antibody, IFB, IFF, IFNB, IFB, Interferon beta, Fibroblast interferon, IFN-beta
Background: Type I Interferons (IFN-alpha/beta) are produced primarily in response to viral infection by "Natural IFN-producing cells" (IPCs) as part of the host immune response and can also inhibit the development of tumors. IFN-beta binding by its receptor results in the activation of the tyrosine kinases Jak1 and Tyk2 and phosphorylation of members of the STAT family of transcription factors, leading to the transcription and expression of the immune response genes. More recently, several members of the toll-like receptor (TLR) family were found to stimulate the production IFN-beta. IFN-beta is currently used clinically for treatment of tumors, infections and multiple sclerosis.
Gene Name: IFNB1
- Gene ID
- JAK-STAT Signaling, TCR Signaling, TLR Signaling, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Autophagy, Inflammasome