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CISD2 antibody (CDGSH Iron Sulfur Domain 2) (Internal Region) Primary Antibody

CISD2 Reactivity: Human ELISA, FM, IHC, WB Host: Rabbit Polyclonal
Catalog No. ABIN6656670
$379.00
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100 μg
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  • Target
    Binding Specificity
    Internal Region
    Reactivity
    Human
    Host
    Rabbit
    Clonality
    Polyclonal
    Conjugate
    This CISD2 antibody is un-conjugated
    Application
    ELISA, Fluorescence Microscopy (FM), Immunohistochemistry (IHC), Western Blotting (WB)
    Cross-Reactivity
    Human, Mouse (Murine), Rat (Rattus)
    Cross-Reactivity (Details)
    Cross reactivity with CISD2 from other sources has not been determined.
    Purification
    Anti-CISD2 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography.
    Immunogen

    Immunogen: Anti-CISD2 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 15 amino acid peptide near the internal region of human CISD2.

    Immunogen Type: Peptide

    Isotype
    IgG
  • Application Notes

    Immunohistochemistry Dilution: User Optimized

    Application Note: Anti-CISD2 Antibody has been tested for use in ELISA, Western Blotting, Immunohistochemistry and Immunofluorescence. Specific conditions for reactivity should be optimized by the end user. Expect a band at approximately 15 kDa in Western Blots of specific cell lysates and tissues.

    ELISA Dilution: User Optimized

    Western Blot Dilution: User Optimized

    IF Microscopy Dilution: User Optimized

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer

    Buffer: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2

    Stabilizer: None

    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    RT,4 °C,-20 °C
    Storage Comment
    Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
  • Target
    Alternative Name
    CISD2 (CISD2 Antibody Abstract)
    Background

    Synonyms: CISD2 Antibody, ERIS, WFS2, ZCD2, NAF-1, Miner1, CDGSH2, ERIS, CDGSH iron-sulfur domain-containing protein 2, Endoplasmic reticulum intermembrane small protein

    Background: Defects in the CISD2 (CDGSH iron sulfur domain 2) gene are a cause of the neurodegenerative disorder Wolfram syndrome 2. CISD2 is a zinc finger protein that localizes to the endoplasmic reticulum and mitochondria and binds an iron/sulfur cluster. CISD2 interacts with Bcl-2 and can be displaced by the BH3-only protein BIK and contributes to the regulation of BIK-initiated autophagy. CISD2 deficiency in mice causes mitochondrial breakdown accompanied by autophagic cell death as well as the development of premature aging phenotype.

    Gene Name: CISD2

    Gene ID
    493856
    NCBI Accession
    NP_001008389
    UniProt
    Q8N5K1
    Pathways
    Activation of Innate immune Response
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