Cytidine Monophosphate (UMP-CMP) Kinase 2, Mitochondrial (CMPK2) (C-Term) antibody Primary Antibody
- Binding Specificity
- ELISA, Fluorescence Microscopy (FM), Western Blotting (WB)
- Human, Mouse (Murine), Rat (Rattus)
- Anti-CMPK2 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Multiple isoforms of CMPK2 are known to exist.
Immunogen: Anti-CMPK2 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 19 amino acid synthetic peptide near the C-terminus of human CMPK2.
Immunogen Type: Peptide
- Application Notes
Application Note: Anti-CMPK2 Antibody has been tested for use in ELISA, Western Blotting and Immunofluorescence. Specific conditions for reactivity should be optimized by the end user. Expect a band at approximately 49 kDa in Western Blots of specific cell lysates and tissues.
ELISA Dilution: 1:10,000
Western Blot Dilution: 1 μg/mL
IF Microscopy Dilution: 20 μg/mL
- For Research Use only
Buffer: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- RT,4 °C,-20 °C
- Storage Comment
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
- Alternative Name
- CMPK2 (CMPK2 Antibody Abstract)
Synonyms: CMPK2 Antibody, TYKi, TMPK2, UMP-CMPK2, UMP-CMP kinase 2, mitochondrial, Nucleoside-diphosphate kinase
Background: UMP-CMP kinase 2 (CMPK2) is the first nucleoside monophosphate kinase that has been identified in human mitochondria. It is a component of the salvage pathway for nucleotide synthesis that may participate in terminal differentiation of monocytic cells. There are two distinct domains of CMPK2: the N-terminal domain with unknown function and the C-terminal domain with the kinase function, suggesting that CMPK2 may be a bifunctional protein with other biological functions in addition to its UMP-CMP kinase activity. CMPK2 may participate in dUTP and dCTP synthesis and is responsible for phosphorylation of dCMP and dUMP in mitochondria. CMPK2 is actively involved in macrophage activation and the inflammatory response
Gene Name: CMPK2
- Gene ID
- NCBI Accession
- Nucleotide Phosphorylation, Cellular Response to Molecule of Bacterial Origin