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TMEM184C antibody (Transmembrane Protein 184C) (C-Term) Primary Antibody

TMEM184C Reactivity: Human ELISA, FM, IHC, WB Host: Rabbit Polyclonal
Catalog No. ABIN6657268
$379.00
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100 μg
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  • Target
    Binding Specificity
    C-Term
    Reactivity
    Human
    Host
    Rabbit
    Clonality
    Polyclonal
    Conjugate
    This TMEM184C antibody is un-conjugated
    Application
    ELISA, Fluorescence Microscopy (FM), Immunohistochemistry (IHC), Western Blotting (WB)
    Cross-Reactivity
    Human, Mouse (Murine), Rat (Rattus)
    Cross-Reactivity (Details)
    Cross reactivity with TMEM184C from other sources has not been determined.
    Purification
    Anti-TMEM184C Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography.
    Immunogen

    Immunogen: Anti-TMEM184C antibody was prepared from whole rabbit serum produced by repeated immunizations with a 15 amino acid synthetic peptide near the C-terminus of human TMEM184C.

    Immunogen Type: Peptide

    Isotype
    IgG
  • Application Notes

    Immunohistochemistry Dilution: 5 μg/mL

    Application Note: Anti-TMEM184C Antibody has been tested for use in ELISA, Western Blotting, Immunohistochemistry and Immunofluorescence. Specific conditions for reactivity should be optimized by the end user. Expect a band at approximately 50 kDa in Western Blots of specific cell lysates and tissues.

    ELISA Dilution: 1:10,000

    Western Blot Dilution: 1 μg/mL

    IF Microscopy Dilution: 20 μg/mL

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer

    Buffer: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2

    Stabilizer: None

    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    RT,4 °C,-20 °C
    Storage Comment
    Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
  • Target
    Alternative Name
    TMEM184C (TMEM184C Antibody Abstract)
    Background

    Synonyms: TMEM184C Antibody, TMEM34, TMEM34, PRO1355, Transmembrane protein 184C, Transmembrane protein 34

    Background: Anaplastic thyroid cancer is one of the most lethal forms of cancer, but the precise carcinogenic mechanism has not been identified. TMEM184C, also known as TMEM34, was identified in a cDNA microarray analysis as being down-regulated in anaplastic thyroid cancers compared to normal thyroid tissues. TMEM184C protein expression was also lower in cell lines derived from these types of cancers compared to that of normal thyroid tissues or cell lines based on other types of thyroid cancers. Furthermore, transfection of TMEM34 into KTA2 cells led to the inhibition of cell growth, suggesting that TMEM184C might act as a tumor suppressor in anaplastic thyroid cancers.

    Gene Name: TMEM184C

    Gene ID
    10430
    NCBI Accession
    NP_116024
    UniProt
    Q9BVK8
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