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PRTFDC1 antibody (phosphoribosyl Transferase Domain Containing 1) (Internal Region) Primary Antibody

PRTFDC1 Reactivity: Human ELISA, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6657416
$379.00
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100 μg
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  • Target
    PRTFDC1
    Binding Specificity
    • 15
    • 9
    • 9
    • 7
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    • 45
    • 22
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 57
    • 3
    Rabbit
    Clonality
    • 58
    • 2
    Polyclonal
    Conjugate
    • 24
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This PRTFDC1 antibody is un-conjugated
    Application
    • 38
    • 29
    • 13
    • 13
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    ELISA, Western Blotting (WB)
    Cross-Reactivity
    Human, Rat (Rattus)
    Cross-Reactivity (Details)
    Cross reactivity with PRTFDC1 from other sources has not been determined.
    Purification
    Anti-PRTFDC1 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography.
    Immunogen

    Immunogen: Anti-PRTFDC1 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 14 amino acid synthetic peptide from near the internal region of human PRTFDC1.

    Immunogen Type: Peptide

    Isotype
    IgG
  • Application Notes

    Application Note: Anti-PRTFDC1 Antibody has been tested for use in ELISA and Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band at approximately 26 kDa in Western Blots of specific cell lysates and tissues.

    ELISA Dilution: 1:10,000

    Western Blot Dilution: 1 μg/mL

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer

    Buffer: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2

    Stabilizer: None

    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    RT,4 °C,-20 °C
    Storage Comment
    Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
  • Target
    PRTFDC1
    Alternative Name
    PRTFDC1 (PRTFDC1 Antibody Abstract)
    Synonyms
    HHGP, HPRT, hprt1, hprt1l, zgc:55561, zgc:86771, MGC80959, OTTMUSG00000011667, Prtfdc1, phosphoribosyl transferase domain containing 1, phosphoribosyl transferase domain containing 1 L homeolog, phosphoribosyltransferase domain containing 1 pseudogene, PRTFDC1, prtfdc1, Prtfdc1, prtfdc1.L, Gm13377
    Background

    Synonyms: PRTFDC1 Antibody, HHGP, HHGP, Phosphoribosyltransferase domain-containing protein 1

    Background: Phosphoribosyl transferase domain containing 1 (PRTFDC1) is highly homologous to the hypoxanthine phosphoribosyltransferase (HPRT1) and may have arisen from a gene duplication event of a common ancestor gene. Recently, it was shown that CpG islands in the PRTFDC1 promoter could be hypermethylated in ovarian cancers and oral squamous-cell carcinomas (OSCC), leading to gene silencing. Restoration of PRTFDC1 expression in OSCC inhibited cell growth in colony-formation assays, while knockdown of PRTFDC1 expression in OSCC that expressed the gene promoted cell growth. These results suggest that PRTFDC1 can act as a tumor-suppressor gene. At least three isoforms of PRTFDC1 are known to exist.

    Gene Name: PRTFDC1

    Gene ID
    56952
    NCBI Accession
    NP_064585
    UniProt
    Q9NRG1
    Pathways
    Ribonucleoside Biosynthetic Process
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