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DLG3 antibody (N-Term)

DLG3 Reactivity: Rat WB, IHC, IP Host: Mouse Monoclonal S19-2 unconjugated
Catalog No. ABIN6658117
  • Target See all DLG3 Antibodies
    DLG3 (Discs, Large Homolog 3 (DLG3))
    Binding Specificity
    • 15
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 36
    • 33
    • 17
    • 5
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Rat
    Host
    • 36
    • 3
    • 1
    Mouse
    Clonality
    • 38
    • 2
    Monoclonal
    Conjugate
    • 19
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This DLG3 antibody is un-conjugated
    Application
    • 32
    • 13
    • 13
    • 7
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
    Cross-Reactivity
    Human, Mouse (Murine), Rat (Rattus)
    Purification
    Anti-SAP102 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with SAP102 from Human, Mouse, and Rat based on 100% homology with the immunizing sequence. No cross-reactivity against PSD95, SAP97 or Chapsyn-110. Cross-reactivity with SAP102 from other sources has not been determined. Organelle Markers, Neurobiology research.
    Immunogen

    Immunogen: SAP102 Antibody was produced in mice by repeated immunizations raised against a fusion protein corresponding to an n-terminal region of rat SAP102.

    Immunogen Type: Recombinant Protein

    Clone
    S19-2
    Isotype
    IgG1
    Top Product
    Discover our top product DLG3 Primary Antibody
  • Application Notes

    Immunohistochemistry Dilution: User Optimized

    Application Note: Anti-SAP102 Antibody is suitable for WB, IP, and IHC. Expect a band approximately 105 kDa protein, corresponding to the molecular mass of SAP102 on SDS Page immunoblots. Specific conditions for reactivity should be optimized by the end user.

    Immunoprecipitation Dilution: User Optimized

    Western Blot Dilution: 1:1000

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer

    Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

    Stabilizer: 50 % (v/v) Glycerol

    0.09 % (w/v) Sodium Azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    RT,4 °C,-20 °C
    Storage Comment
    Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
  • Target
    DLG3 (Discs, Large Homolog 3 (DLG3))
    Alternative Name
    SAP102 (DLG3 Products)
    Synonyms
    MRX antibody, MRX90 antibody, NEDLG antibody, SAP102 antibody, XLMR antibody, DLG3 antibody, fa66c08 antibody, fa66e02 antibody, fd02c12 antibody, fu95c12 antibody, im:7138640 antibody, si:ch211-276g21.1 antibody, wu:fa66c08 antibody, wu:fa66e02 antibody, wu:fd02c12 antibody, wu:fu95c12 antibody, Dlgh3 antibody, mKIAA1232 antibody, MPP3 antibody, 6430514B01 antibody, CSG18 antibody, Dlg3 antibody, Dusp3 antibody, discs large MAGUK scaffold protein 3 antibody, membrane palmitoylated protein 3 antibody, discs, large homolog 3 (Drosophila) antibody, membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) antibody, DLG3 antibody, MPP3 antibody, dlg3 antibody, Dlg3 antibody, Mpp3 antibody
    Background

    Synonyms: DLG3, MRX90, NEDLG, XLMR, Disks large homolog 3, PSD-95/SAP90-related protein 1, Synapse-associated protein 102, SAP-102

    Background: Synapse-associated protein 102 belongs to the membrane-associated guanylate kinase protein family and is a homolog of the Drosophila dis large tumor suppressor protein. SAP102 has extensive sequence homology to the PSD 95 family of proteins that facilitate ion channel clustering at synaptic terminal. SAP102 consists of three 90 amino acids PDZ domains at its amino terminus, a Src homolgy 3 domain and a guanylate kinase domain. All three PDZ domains of SAP102 participate in binding to the NMDA reception, interacting specifically with the carboxy-terminal domain of the N-methyl-D-aspartate receptor 2B (NR2B). The interaction may facilitate AMPA receptor withdrawal from the postsynaptic membrane by inhibiting the ERK/MAPK pathway. SAP102 also interacts with synaptic ras-GTPase activating protein synGAP through its PDZ domains. In general, the SAP102 protein is more highly expressed in non-proliferating cells than in proliferating cells, indicating a role in the negative regulation of cell growth.

    Gene Name: Dlg3

    Gene ID
    58948
    NCBI Accession
    NP_113827
    UniProt
    Q62936
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