SCN8A antibody
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- Target See all SCN8A Antibodies
- SCN8A (Sodium Channel, Voltage-Gated, Type VIII, alpha (SCN8A))
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Reactivity
- Rat
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This SCN8A antibody is un-conjugated
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Application
- Immunohistochemistry (IHC), Immunoprecipitation (IP)
- Cross-Reactivity
- Human, Mouse (Murine), Rat (Rattus)
- Purification
- Anti-Nav1.6 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with Nav1.6 from Mouse, Human, and Rat based on 100% homology with the immunizing sequence. Cross-reactivity with Nav1.6 from other sources has not been determined. Ion Channels research.
- Immunogen
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Immunogen: Nav1.6 Antibody was produced in mice by repeated immunizations raised against a synthetic peptide corresponding to the intracellular interdomain loop I-II of rat Nav1.6.
Immunogen Type: Peptide
- Clone
- S87A-10
- Isotype
- IgG1
- Top Product
- Discover our top product SCN8A Primary Antibody
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- Application Notes
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Immunohistochemistry Dilution: 0.1-1.0 μg/mL
Application Note: Anti-Nav1.6 Antibody is suitable for use in IP and IHC. Specific conditions for reactivity should be optimized by the end user.
Immunoprecipitation Dilution: User Optimized
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Stabilizer: 50 % (v/v) Glycerol
0.09 % (w/v) Sodium Azide - Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- RT,4 °C,-20 °C
- Storage Comment
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
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- Target
- SCN8A (Sodium Channel, Voltage-Gated, Type VIII, alpha (SCN8A))
- Alternative Name
- Nav1.6 (SCN8A Products)
- Synonyms
- CERIII antibody, CIAT antibody, EIEE13 antibody, MED antibody, NaCh6 antibody, Nav1.6 antibody, PN4 antibody, AI853486 antibody, C630029C19Rik antibody, dmu antibody, med antibody, mnd-2 antibody, mnd2 antibody, nmf2 antibody, nmf335 antibody, nmf58 antibody, nur14 antibody, seal antibody, sodium voltage-gated channel alpha subunit 8 antibody, sodium channel, voltage-gated, type VIII, alpha antibody, SCN8A antibody, Scn8a antibody
- Background
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Synonyms: Scn8A, Sodium channel protein type 8 subunit alpha, Peripheral nerve protein type 4, PN4, Sodium channel 6, NaCh6, Sodium channel protein type VIII subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.6
Background: Voltage gated sodium channels initiate action potentials in neurons. Nav1.6 subunits have been assessed to meditate resurgent and persistent sodium currents in cells with a resulting effect on repetitive firing behavior. Nav1.6 subunits have been found to activate at more negative voltages than other Nav subunits.
Gene Name: Scn8a
- Gene ID
- 29710
- NCBI Accession
- NP_062139
- UniProt
- O88420
- Pathways
- Sensory Perception of Sound
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