GABRG2 antibody (Cytoplasmic Loop)
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- Target See all GABRG2 Antibodies
- GABRG2 (gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2))
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Binding Specificity
- Cytoplasmic Loop
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Reactivity
- Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This GABRG2 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Cross-Reactivity
- Mouse (Murine), Rat (Rattus)
- Purification
- Anti-GABA(A) Receptor gamma 2 Antibody is directed against rat GABA(A) Receptor gamma 2. The antibody was affinity purified from monospecific antiserum by immune affinity purification. Reactivity is expected from the following species based on 100% sequence homology: bovine, chicken, canine, human, mouse, and non-human primate.
- Immunogen
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Immunogen: Anti-GABA(A) Receptor gamma 2 Antibody was produced by repeated immunizations with recombinant fusion proteins from the cytoplasmic loop of the gamma 2 subunit.
Immunogen Type: Recombinant Protein
- Isotype
- IgG
- Top Product
- Discover our top product GABRG2 Primary Antibody
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- Application Notes
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Immunohistochemistry Dilution: 1:100
Application Note: Anti-GABA(A) Receptor gamma 2 (Rabbit) antibody is suitable for use in Western Blotting and IHC. Specific conditions for reactivity should be optimized by the end user. Expect a band of 46 kDa in size corresponding to the gamma 2 subunit of the GABA(A) receptor in the appropriate cell lysate or extract.
Western Blot Dilution: 1:1000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5
Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol
- Storage
- 4 °C,-20 °C
- Storage Comment
- Store vial at -20° C prior to opening. This product is stable at 4° C as an undiluted liquid. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Dilute only prior to immediate use.
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- Target
- GABRG2 (gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2))
- Alternative Name
- GABA(A) Receptor gamma 2 (GABRG2 Products)
- Synonyms
- cae2 antibody, eca2 antibody, gabrg1 antibody, gefsp3 antibody, si:ch211-145n14.1 antibody, CAE2 antibody, ECA2 antibody, GEFSP3 antibody, GABAA-R antibody, Gabrg-2 antibody, gamma2 antibody, gamma-aminobutyric acid type A receptor gamma2 subunit antibody, gamma-aminobutyric acid (GABA) A receptor, gamma 2 antibody, gamma-aminobutyric acid type A receptor gamma 2 subunit antibody, gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 antibody, GABRG2 antibody, gabrg2 antibody, Gabrg2 antibody
- Background
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Synonyms: Gamma-aminobutyric acid receptor subunit gamma-2, GABA(A) receptor subunit gamma-2, Gabrg2
Background: Anti-GABA(A) Receptor gamma 2 Antibody detects GABA(A) Receptor gamma 2. Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha-subunits of the receptor. Anti-GABA(A) Receptor gamma 2 Antibody is ideal for investigators involved in Neuroscience.
Gene Name: GABRG2
- Gene ID
- 29709
- NCBI Accession
- NP_899156
- UniProt
- P18508
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