GABRB1 antibody (Cytoplasmic Loop)

Catalog No. ABIN6658240

Supplier Product No.: 612-401-d49

The Rabbit Polyclonal anti-GABRB1 antibody has been validated for WB. It is suitable to detect GABRB1 in samples from Rat.

Quick Overview for GABRB1 antibody (Cytoplasmic Loop) (ABIN6658240)

Target: GABRB1 (gamma-aminobutyric Acid (GABA) A Receptor, Subunit beta 1 (GABRB1))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GABRB1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GABRB1 Antibody

Binding Specificity: Cytoplasmic Loop

Supplier Product No.: 612-401-d49

Supplier: Rockland

Purpose: GABA(A) Receptor beta 1 Antibody

Cross-Reactivity (Details): Anti-GABA(A) Receptor beta 1 Antibody is directed against rat GABA(A) Receptor beta 1.

Purification: The antibody was affinity purified from monospecific antiserum by immunoaffinity purification.

Immunogen: Anti-GABA(A) Receptor beta 1 Antibody was produced by repeated immunizations with recombinant fusion proteins from the cytoplasmic loop of the beta 1 subunit of rat GABAA.

Isotype: IgG

Application Details

Application Notes: Optional[Neutralization_Dilution]: 1:1000

Comment:

Anti-GABA(A) Receptor beta 1 (Rabbit) antibody is tested for use in Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 55 kDa in size corresponding to the beta 1 subunit of the GABA(A) receptor in the appropriate cell lysate or extract.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Storage: 4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Expiry Date: 12 months

Target Details for GABRB1

Target: GABRB1 (gamma-aminobutyric Acid (GABA) A Receptor, Subunit beta 1 (GABRB1))

Alternative Name: GABA(A) Receptor beta 1

Background:

Synonyms: Gamma-aminobutyric acid receptor subunit beta-1, GABA(A) receptor subunit beta-1, GABA(A) receptor subunit ß-1,

Background: Anti-GABA(A) Receptor beta 1 Antibody detects GABA(A) Receptor beta 1. Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma- subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different α-subunits of the receptor. GABA(A) receptor beta 1 antibody is ideal for investigators involved in Neuroscience.

Gene Name: GABRB1

Gene ID: 25450

UniProt: P15431