NFKBIA antibody (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha)

Details for Product anti-NFKBIA Antibody No. ABIN6672616
Antigen
  • IKBA
  • MAD-3
  • NFKBI
  • AI462015
  • Nfkbi
  • RL/IF-1
  • ECI-6/IKBA
  • ikbaA
  • wu:fj16a07
  • zgc:85769
  • NFKB inhibitor alpha
  • nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
  • nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a
  • NFKBIA
  • Nfkbia
  • nfkbiaa
Alternatives
anti-Human NFKBIA antibody for Immunohistochemistry
Reactivity
Human, Mouse (Murine), Rat (Rattus)
503
316
249
32
22
20
19
9
2
2
2
1
1
Host
Rabbit
446
64
7
7
Clonality
Polyclonal
Conjugate
This NFKBIA antibody is un-conjugated
24
13
13
13
13
13
13
10
9
6
6
6
3
3
3
3
3
Application
Immunohistochemistry (IHC), Western Blotting (WB)
354
175
174
81
70
62
41
21
19
18
18
7
6
4
3
1
1
1
Options
Immunogen Recombinant protein of human NFKBIA
Isotype IgG
Purification Affinity purification
Plasmids, Primers & others Plasmids, Primers & others NFKBIA products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name NFKBIA (NFKBIA Antibody Abstract)
Background The NF-kappaB/Rel transcription factors are present in the cytosol in an inactive state complexed with the inhibitory IkappaB proteins. Activation occurs via phosphorylation of IkappaBalpha at Ser32 and Ser36 followed by proteasome-mediated degradation that results in the release and nuclear translocation of active NF-kappaB. IkappaBalpha phosphorylation and resulting Rel-dependent transcription are activated by a highly diverse group of extracellular signals including inflammatory cytokines, growth factors, and chemokines. Kinases that phosphorylate IkappaB at these activating sites have been identified.
Synonyms: NFKBIA, IKBA, MAD-3, NFKBI
Gene ID 4792
UniProt P25963
Pathways NF-kappaB Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Maintenance of Protein Location, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades
Application Notes Recommended dilutions: WB: 1:500-1:2000, IHC: 1:50-1:200
Restrictions For Research Use only
Format Liquid
Buffer PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze / thaw cycles
Storage -20 °C,-80 °C
Storage Comment

Storage: -20 °C/-80 °C

Supplier Images
Immunohistochemistry (IHC) image for anti-Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA) antibody (ABIN6672616) anti-Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA) antibody
Western Blotting (WB) image for anti-Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA) antibody (ABIN6672616) Western blot analysis of extracts of various cell lines, using NFKBIA antibody.
Immunofluorescence (IF) image for anti-Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA) antibody (ABIN6672616) Immunofluorescence analysis of HeLa cell using NFKBIA antibody. Blue: DAPI for nuclea...
Immunofluorescence (IF) image for anti-Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA) antibody (ABIN6672616) anti-Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA) antibody (Image 4)
Western Blotting (WB) image for anti-Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA) antibody (ABIN6672616) Western blot analysis of extracts of various cell lines, using NFKBIA antibody.
Product cited in: He, Zhao, Anees, Li, Ashraf, Chen, Song, Chen, Cao, Ye: "p21-Activated Kinase 4 Signaling Promotes Japanese Encephalitis Virus-Mediated Inflammation in Astrocytes." in: Frontiers in cellular and infection microbiology, Vol. 7, pp. 271, 2018 (PubMed). Method employed by authors: Western Blotting (WB)

Dong, Liu, Meng, Liu, Bi, Wu, Jin, Yao, Tang, Wang, Li, Zhang, Yu, Zhan, Chen, Ge, Yang, Li: "Keratin 8 limits TLR-triggered inflammatory responses through inhibiting TRAF6 polyubiquitination." in: Scientific reports, Vol. 6, pp. 32710, 2018 (PubMed). Method employed by authors: Western Blotting (WB)

Li, Xu, Rao, Li, Zhang, Jiang, Wu: "Mechanism of Apoptosis Induction by Mycoplasmal Nuclease MGA_0676 in Chicken Embryo Fibroblasts." in: Frontiers in cellular and infection microbiology, Vol. 8, pp. 105, 2018 (PubMed). Method employed by authors: Western Blotting (WB)

Ding, Huang, Chen, Tang, Wang, Fan, Huang: "Regulator of G-protein signalling 5 deficiency impairs ventricular remodelling after myocardial infarction by promoting NF-κB and MAPK signalling in mice." in: Biochemical and biophysical research communications, Vol. 499, Issue 2, pp. 143-149, 2018 (PubMed). Method employed by authors: Western Blotting (WB)

Li, Zhang, Zhu, Ashraf, Chen, Xu, Zhou, Zheng, Song, Chen, Ye, Cao: "Microarray Analysis Identifies the Potential Role of Long Non-Coding RNA in Regulating Neuroinflammation during Japanese Encephalitis Virus Infection." in: Frontiers in immunology, Vol. 8, pp. 1237, 2017 (PubMed). Method employed by authors: Western Blotting (WB)

Ye, Chen, Li, Zhao, He, Zohaib, Song, Deng, Zhang, Chen, Cao: "Japanese Encephalitis Virus NS5 Inhibits Type I Interferon (IFN) Production by Blocking the Nuclear Translocation of IFN Regulatory Factor 3 and NF-κB." in: Journal of virology, Vol. 91, Issue 8, 2017 (PubMed). Method employed by authors: Western Blotting (WB)

Song, Xiong, Guan, Cao, Manyande, Zhou, Zheng, Tian: "Minocycline attenuates bone cancer pain in rats by inhibiting NF-κB in spinal astrocytes." in: Acta pharmacologica Sinica, Vol. 37, Issue 6, pp. 753-62, 2017 (PubMed). Method employed by authors: Western Blotting (WB)

Song, Li, Li, Ma, Bai, Wen, Zhang, Chen, Peng: "Exposure to PM2.5 induces aberrant activation of NF-κB in human airway epithelial cells by downregulating miR-331 expression." in: Environmental toxicology and pharmacology, Vol. 50, pp. 192-199, 2017 (PubMed). Method employed by authors: Immunofluorescence (IF)

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