MMP 9 antibody (AA 611-707)

Catalog No. ABIN668095

Product Details anti-MMP 9 Antibody

Target: MMP 9 (MMP9) (Matrix Metallopeptidase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa Type IV Collagenase) (MMP9))

Binding Specificity: AA 611-707

Reactivity: Human, Rat, Mouse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MMP 9 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human, Mouse, Rabbit, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MMP9

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-MMP 9 antibody (ABIN668095)

Borin, Shankar, Angara, Rashid, Jain, Iskander, Ara, Lebedyeva, Korkaya, Achyut, Arbab: "HET0016 decreases lung metastasis from breast cancer in immune-competent mouse model." in: PLoS ONE, Vol. 12, Issue 6, pp. e0178830, (2017) (PubMed).

Wu, Zhu, Sun, Hu: "Subchondral bone changes and chondrogenic capacity of progenitor cells from subchondral bone in the collagenase-induced temporomandibular joints osteoarthritis rabbit model." in: International journal of clinical and experimental pathology, Vol. 8, Issue 9, pp. 9782-9, (2016) (PubMed).

Basak, Das, Srinivas, Duttaroy: "The interplay between glucose and fatty acids on tube formation and fatty acid uptake in the first trimester trophoblast cells, HTR8/SVneo." in: Molecular and cellular biochemistry, Vol. 401, Issue 1-2, pp. 11-9, (2015) (PubMed).

Koronyo, Salumbides, Sheyn, Pelissier, Li, Ljubimov, Moyseyev, Daley, Fuchs, Pham, Black, Rentsendorj, Koronyo-Hamaoui: "Therapeutic effects of glatiramer acetate and grafted CD115+ monocytes in a mouse model of Alzheimer's disease." in: Brain : a journal of neurology, Vol. 138, Issue Pt 8, pp. 2399-422, (2015) (PubMed).

Zhao, Xu, He, Hua, Luo, Zuo: "Expression of serum response factor in gastric carcinoma and its molecular mechanisms involved in the regulation of the invasion and migration of SGC-7901 cells." in: Cancer biotherapy & radiopharmaceuticals, Vol. 28, Issue 2, pp. 146-52, (2013) (PubMed).

Qin, Fan, Zhao, Cui, Wei, Kohama, Gordon, Li, Gao: "Recombinant human CXCL8(3-72)K11R/G31P regulates smooth muscle cell proliferation and migration through blockage of interleukin-8 receptor." in: IUBMB life, Vol. 65, Issue 1, pp. 67-75, (2013) (PubMed).

Zhao, Zhang, Li, Cui, Shi, Yuan: "Differential expression of MMP-9 and AQP4 in human glioma samples." in: Folia neuropathologica / Association of Polish Neuropathologists and Medical Research Centre, Polish Academy of Sciences, Vol. 50, Issue 2, pp. 176-86, (2012) (PubMed).

Zhao, Huang, Wang, Zhong: "Inhibition of NF-kappaB activation by Pyrrolidine dithiocarbamate partially attenuates hippocampal MMP-9 activation and improves cognitive deficits in streptozotocin-induced diabetic rats." in: Behavioural brain research, Vol. 238, pp. 44-7, (2012) (PubMed).

Target Details for MMP 9

Target: MMP 9 (MMP9) (Matrix Metallopeptidase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa Type IV Collagenase) (MMP9))

Alternative Name: MMP9 (MMP9 Products)

Synonyms: CLG4B antibody, GELB antibody, MANDP2 antibody, MMP-9 antibody, AW743869 antibody, B/MMP9 antibody, Clg4b antibody, pro-MMP-9 antibody, mmp-9 antibody, fgMMP-9 antibody, mmp9 antibody, ZFMMP-9 antibody, wu:fb02g06 antibody, wu:fb07b05 antibody, wu:fi98c09 antibody, wu:fj05a08 antibody, zgc:64165 antibody, clg4b antibody, gelb antibody, mandp2 antibody, matrix metallopeptidase 9 antibody, collagenase antibody, matrix metalloproteinase 9 antibody, matrix metallopeptidase 9 S homeolog antibody, MMP9 antibody, RB3913 antibody, BPSS0666 antibody, Sbal_3732 antibody, Bcer98_0486 antibody, Shew185_0630 antibody, Shal_3056 antibody, Sbal195_0657 antibody, Lbys_3550 antibody, Palpr_2084 antibody, Mmp9 antibody, mmp9 antibody, mmp9.S antibody

Background:

Synonyms: GELB, CLG4B, MMP-9, MANDP2, Matrix metalloproteinase-9, 92 kDa gelatinase, 92 kDa type IV collagenase, Gelatinase B, MMP9

Background: May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.

Gene ID: 4318

UniProt: P14780

Pathways: Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events